1394047-29-0

Basic information

• Product Name: C₂₉H₂₉ClN₆O₂S
• CAS NO: 1394047-29-0
• Molecular Weight: 561.107
• Mol File: 1394047-29-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₉H₂₉ClN₆O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₉H₂₉ClN₆O₂S(1394047-29-0)
• EPA Substance Registry System: C₂₉H₂₉ClN₆O₂S(1394047-29-0)

Safety Data

• Hazardous Substances Data: 1394047-29-0(Hazardous Substances Data)

Upstream product

• 16233-51-5 1H-thieno[3,2-d]pyrimidine-2,4-dione 
• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 16234-15-4 2-chloro-4-morpholinothieno[3,2-d]pyrimidine 
• 1033743-25-7 2-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)propan-2-ol 
• 1415660-22-8 C₁₃H₁₉N₅O₂S 
• 75629-57-1 oncrasin-1 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 487-89-8 Indole-3-carboxaldehyde 

Relevant articles and documents

Design, synthesis and 3D-QSAR analysis of novel 2-hydrazinyl-4- morpholinothieno[3,2-d]pyrimidine derivatives as potential antitumor agents

A series of 2-hydrazinyl-4-morpholinothieno[3,2-d]pyrimidine derivatives were synthesized and evaluated for their cytotoxic activities against five cancer cell lines. Most of them exhibited moderate to significant cytotoxic activities and high-selectivity against one or more cell lines, and nearly all of them had higher potency than positive controls against MDA-MB-231 cell line. The most promising compound 15f showed strong cytotoxic activities against H460, HT-29 and MDA-MB-231 cell lines, which were 1.7- to 66.5-folds more active than 2-(1H-Indazol-4-yl)-6-((4-(methylsulfonyl)-1-piperazinyl)methyl)-4-(4- morpholinyl)thieno[3,2-d]pyrimidine(GDC-0941). To investigate the SARs of thieno[3,2-d]pyrimidine derivatives in more details, CoMFA (q2 = 0.436, r2 = 0.937) and CoMSIA (q2 = 0.706, r2 = 0.947) models on H460 cell line were established. The generated 3D-QSAR models can be used for further rational design of novel thienopyrimidines as highly potent and selective cytotoxic agents.