1394050-67-9

Basic information

• Product Name: C₂₉H₃₇NO₅
• Synonyms: C₂₉H₃₇NO₅
• CAS NO: 1394050-67-9
• Molecular Weight: 479.616
• Mol File: 1394050-67-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: C₂₉H₃₇NO₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₉H₃₇NO₅(1394050-67-9)
• EPA Substance Registry System: C₂₉H₃₇NO₅(1394050-67-9)

Safety Data

• Hazardous Substances Data: 1394050-67-9(Hazardous Substances Data)

Upstream product

• 1394050-28-2 (3S,5R)-5-(biphenyl-4-yl-methyl)-3-(hydroxymethyl)-3-methylpyrrolidin-2-one 
• 1394050-66-8 C₂₄H₂₇NO₅ 
• 1394050-22-6 [(R)-1-(biphenyl-4-yl)-methyl-2-(2,2,5-trimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-ethyl]-carbamic acid t-butyl ester 
• 1383026-42-3 [(S)-2-biphenyl-4-yl-1-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-ylmethyl)ethyl]carbamic acid t-butyl ester 
• 1383026-37-6 [(R)-1-biphenyl-4-ylmethyl-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-2-oxoethyl]carbamic acid t-butyl ester 
• 1038925-12-0 C₁₉H₁₉NO₃ 
• 1038925-08-4 (3R,5R)-5-(biphenyl-4-yl)methyl-3-methyl-2-oxopyrrolidine-3-carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1394050-29-3 C₂₄H₂₉NO₃ 
• 128779-47-5 (2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid 

Downstream Products

• 1394050-31-7 (2S,4R)-4-amino-5-biphenyl-4-yl-2-(hydroxymethyl)-2-methylpentanoic acid (5-methyl-2-oxo-[1,3]-dioxol-4-yl)methyl ester hydrochloride 
• 1394050-47-5 C₃₄H₄₃NO₉ 
• 1562404-94-7 (2S,4R)-5-biphenyl-4-yl-2-methyl-2-(tetrahydropyran-2-yloxymethyl)-4-[(1-trityl-1H-1,2,3-triazole-4-carbonyl)amino]pentanoic acid benzyl ester 
• 1562404-70-9 (2S,4R)-5-biphenyl-4-yl-2-methyl-2-(tetrahydropyran-2-yloxymethyl)-4-[(1-trityl-1H-1,2,3-triazole-4-carbonyl)amino]pentanoic acid 
• 1562404-16-3 (2S,4R)-5-biphenyl-4-yl-2-isobutyryloxymethyl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)amino]pentanoic Acid 
• 1562404-15-2 (2S,4R)-2-acetoxymethyl-5-biphenyl-4-yl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)amino]pentanoic Acid 
• 1562375-65-8 (2S,4R)-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)-amino]pentanoic acid 5-t-Butyl-2-oxo-[1,3]dioxol-4-ylmethyl ester 
• 1394050-32-8 (2S,4R)-5-biphenyl-4-yl-2-methyl-2-(tetrahydropyran-2-yloxymethyl)-4-[((1-trityl)-1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid (5-methyl-2-oxo-[1,3]dioxol-4-yl)methyl ester 
• 1394050-44-2 C₂₉H₃₅NO₇ 
• 1394049-42-3 (2S,4R)-5-(biphenyl-4-yl)-2-hydroxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid (5-methyl-2-oxo-[1,3]dioxol-4-yl)-methyl ester 

Relevant articles and documents

NEPRILYSIN INHIBITORS

In one aspect, the invention relates to compounds having the formula: where X, Ra, Rb, R2, and R7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds are prodrugs

CRYSTALLINE FORM OF (2S,4R)-5-BIPHENYL-4-YL-2-HYDROXYMETHYL-2-METHYL-4-[(1H-[1,2,3]TRIAZOLE-4-CARBONYL)-AMINO]-PENTANOIC ACID 5-METHYL-2-OXO-[1,3]DIOXOL-4-YLMETHYL ESTER

The invention provides a crystalline form of (2S,4R)-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester or its tautomer. This invention also provides pharmaceutical compositions comprising the crystalline compound, processes and intermediates for preparing the crystalline compound, and methods of using the crystalline compound to treat diseases.