1394122-87-2Relevant academic research and scientific papers
Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV
Manchester, John I.,Dussault, Daemian D.,Rose, Jonathan A.,Boriack-Sjodin, P. Ann,Uria-Nickelsen, Maria,Ioannidis, Georgine,Bist, Shanta,Fleming, Paul,Hull, Kenneth G.
, p. 5150 - 5156 (2012)
We present the discovery and optimization of a novel series of bacterial topoisomerase inhibitors. Starting from a virtual screening hit, activity was optimized through a combination of structure-based design and physical property optimization. Synthesis
