1394129-52-2Relevant academic research and scientific papers
Synthesis, 5-hydroxytryptamine1A receptor affinity and docking studies of 3-[3-(4-aryl-1-piperazinyl)-propyl]-1H-indole derivatives
Pessoa-Mahana, Hernan,Nunez, Catalina Ugarte,Araya-Maturana, Ramiro,Barria, Claudio Saitz,Zapata-Torres, Gerald,Pessoa-Mahana, Carlos David,Iturriaga-Vasquez, Patricio,Mella-Raipan, Jaime,Reyes-Parada, Miguel,Celis-Barros, Cristian
, p. 632 - 638 (2012)
A series of 3-[3-(4-aryl-1-piperazinyl)-propyl]-1H-indole derivatives (12a-h) was synthesized and evaluated for binding affinity at the human 5-hydroxytryptamine1A receptor (5-HT1AR) compounds (12b) and (12h) showed the highest 5-HT1A receptor affinity (IC 50-=15 nM). Molecular docking studies with all the compounds in a homology model of 5-HT1A showed that the main interaction anchoring the ligand in the receptor was a charge-reinforced bond between the protonated nitrogen atom (N-4) of the piperazine ring and Aspartate3.32.
