3569-21-9

Basic information

• Product Name: 3-(1H-Indol-3-yl)-propan-1-ol
• Synonyms: RARECHEM AH BS 0116;INDOLE-3-PROPANOL;HOMOTRYPTOPHOL;1H-INDOLE-3-PROPANOL;3-(3-HYDROXYPROPYL)INDOLE;3-(1H-INDOL-3-YL)-PROPAN-1-OL;3-(3-Hydroxypropyl)-1H-indole;3-Indolepropanol
• CAS NO: 3569-21-9
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.23
• EINECS: 222-667-9
• Product Categories: Indoles and derivatives;pharmacetical;Indoles;Simple Indoles
• Mol File: 3569-21-9.mol
• Article Data: 56

Chemical Properties

• Boiling Point: 200 °C / 2mmHg
• Flash Point: >110℃
• Appearance: /
• Density: 1,13 g/cm3
• Vapor Pressure: 4.02E-06mmHg at 25°C
• Refractive Index: n20/D1.605
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(1H-Indol-3-yl)-propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1H-Indol-3-yl)-propan-1-ol(3569-21-9)
• EPA Substance Registry System: 3-(1H-Indol-3-yl)-propan-1-ol(3569-21-9)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 3569-21-9(Hazardous Substances Data)

Usage

Uses

Indole-3-propanol is an indole derivative that may be capable of the potentiation of Francisella resistance to conventional antibiotics.

InChI:InChI=1/C11H13NO/c13-7-3-4-9-8-12-11-6-2-1-5-10(9)11/h1-2,5-6,8,12-13H,3-4,7H2

Upstream product

• 830-96-6 Indole-3-propionic acid 
• 4221-03-8 5-hydroxypentanal 
• 615-43-0 2-iodophenylamine 
• 110-87-2 3,4-dihydro-2H-pyran 
• 100-63-0 phenylhydrazine 
• 3174-74-1 dihydropyran 
• 59-88-1 phenylhydrazine hydrochloride 
• 64-19-7 acetic acid 
• 120-72-9 indole 
• 95-51-2 o-chloroaniline 
• 360788-02-9 3-(1H-indol-3-yl)propionaldehyde 
• 67-56-1 methanol 
• 141972-19-2 3-(indol-3'-yl)propyl trichloroacetate 
• 5548-09-4 Methyl indole-3-propionate 

Downstream Products

• 1027267-22-6 3-[1-(4-fluorophenyl)-1H-indol-3-yl]propan-1-ol 
• 1452806-88-0 2-(4-(3-(1H-indol-3-yl)propyl)piperazin-1-yl)-Ncyclohexyl-N-phenylacetamide 
• 1452806-89-1 2-(4-(3-(1H-indol-3-yl)propyl)piperazin-1-yl)-Ncyclohexyl-N-(2-methoxyphenyl)acetamide 
• 1587712-63-7 3-[3-(4-{4-(trifluoromethyl)phenyl}-1-piperazinyl)propyl]-1H-indole 
• 1587712-65-9 3-[3-(4-{2-fluorobenzyl}-1-piperazinyl)propyl]-1H-indole 
• 1587712-67-1 3-[3-(4-phenylethyl-1-piperazinyl)propyl]-1H-indole 
• 1587712-74-0 3-[3-(3-{4-fluorophenyl}-1H-1-pyrazolyl)propyl]-1H-indole 
• 1587712-80-8 1-[3-(3-indolyl)propyl]-2-(2-nitrophenyl-)1H-benzo[d]-imidazole 

Relevant articles and documents

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Dearomatization-Rearomatization Strategy for ortho-Selective Alkylation of Phenols with Primary Alcohols

Phenols are common precursors and core structures of a variety of industrial chemicals ranging from pharmaceuticals to polymers. However, the synthesis of site-specifically substituted phenols is challenging, and thus the development of new methods for this purpose would be highly desirable. Reported here is a protocol for palladium-catalyzed ortho-selective alkylation reactions of phenols with primary alcohols by a dearomatization-rearomatization strategy, with water as the sole by-product. Various substituted phenols and primary alcohols were compatible with the standard reaction conditions. The detailed mechanism of this transformation was also investigated.

HYDROXYL PURINE COMPOUNDS AND USE THEREOF

Disclosed are a series of hydroxyl purine compounds and the use thereof as PDE2 or TNFα inhibitors, in particular, the compounds as shown in formula (I), or tautomers thereof or pharmaceutically acceptable salts thereof.