1394159-49-9Relevant academic research and scientific papers
Regioselective Iron-Catalyzed [2 + 2 + 2] Cycloaddition Reaction Forming 4,6-Disubstituted 2-Aminopyridines from Terminal Alkynes and Cyanamides
Spahn, Nathan A.,Nguyen, Minh H.,Renner, Jonas,Lane, Timothy K.,Louie, Janis
, p. 234 - 242 (2017)
Iron complexes bound by redox-active pyridine dialdimine (PDAI) ligands catalyze the cycloaddition of two terminal alkynes and one cyanamide. The reaction is both chemo- and regioselective, as only 4,6-disubstituted 2-aminopyridine products are formed in moderate to high yields. Isolation of an iron azametallacycle (4) suggests that catalyst deactivation occurs with a large excess of cyanamide over longer reaction times. Fe-catalyzed cycloaddition allowed for a straightforward synthesis of a variety of aminopyridines, including known estrogen receptor ligands.
Iron-catalyzed formation of 2-aminopyridines from diynes and cyanamides
Lane, Timothy K.,D'Souza, Brendan R.,Louie, Janis
, p. 7555 - 7563 (2012/11/07)
Diynes and cyanamides undergo an iron-catalyzed [2 + 2 + 2] cycloaddition to form highly substituted 2-aminopyridines in an atom-efficient manner that is both high yielding and regioselective. This system was also used to cyclize two terminal alkynes and
