139417-75-7

Upstream product

• 1640-39-7 2,3,3-trimethylindoleniune 
• 100-39-0 benzyl bromide 

Downstream Products

• 1211408-72-8 1,1'-dibenzyl-3,3,3',3'-tetramethylindotricarbocyanine bromide 
• 958885-95-5 C₄₁H₄₁ClN₄O 
• 1315377-21-9 2-(4-((E)-2-((E)-3-((E)-2-(1-benzyl-3,3-dimethylindolin-2-ylidene)ethylidene)-5-tert-butyl-2-(4-(3-azidopropyl)phenoxy)cyclohex-1-enyl)vinyl)-3-cyano-5,5-dimethylfuran-2(5H)-ylidene)malononitrile 
• 1315377-09-3 2-(4-((E)-2-((E)-3-((E)-2-(1-benzyl-3,3-dimethylindolin-2-ylidene)ethylidene)-2-(4-bromophenylthio)-5-tert-butylcyclohex-1-enyl)vinyl)-3-cyano-5,5-dimethylfuran-2(5H)-ylidene)malononitrile 
• 1315377-07-1 2-(4-((E)-2-((E)-3-((E)-2-(1-benzyl-3,3-dimethylindolin-2-ylidene)ethylidene)-5-tert-butyl-2-(1-hexyl-1H-1,2,3-triazol-4-yl)cyclohex-1-enyl)vinyl)-3-cyano-5,5-dimethylfuran-2(5H)-ylidene)malononitrile 
• 1315377-05-9 2-(4-((E)-2-((E)-3-((E)-2-(1-benzyl-3,3-dimethylindolin-2-ylidene)ethylidene)-5-tert-butyl-2-((trimethylsilyl)ethynyl)cyclohex-1-enyl)vinyl)-3-cyano-5,5-dimethylfuran-2(5H)-ylidene)malononitrile 
• 1315377-04-8 2-(4-((E)-2-((E)-3-((E)-2-(1-benzyl-3,3-dimethylindolin-2-ylidene)ethylidene)-5-tert-butyl-2-(phenoxy)cyclohex-1-enyl)vinyl)-3-cyano-5,5-dimethylfuran-2(5H)-ylidene)malononitrile 
• 1424352-04-4 C₃₂H₃₃N₂O₂⁽¹⁺⁾*Br^(1-) 

Relevant academic research and scientific papers

Concise multigram-scale synthesis of push-pull tricyanofuran-based hemicyanines with giant second-order nonlinearity: An alternative for electro-optic materials

Highly stable and highly soluble push-pull heptamethine hemicyanines based on the tricyanofuran electron-accepting group can be prepared on a 15 g scale. The compounds display giant second-order nonlinear figure of merit, μβ of up to 31 000×10-48 esu, and lead to a poled material with a second-order nonlinear response, r33 of 90 pm V-1 at 1.06 μm Highly stable and highly soluble push-pull heptamethine hemicyanines based on the tricyanofuran electron-accepting group (see figure) can be prepared on a 15 g scale. The compounds display giant second-order nonlinear figure of merit, μβ of up to 31 000×10-48 esu, and lead to a poled material with a second-order nonlinear response, r33 of 90 pm V -1 at 1.06 μm.

Active inorganic sulfur species two-photon fluorescent probe as well as synthesis method and application thereof

The invention relates to an active inorganic sulfur species two-photon fluorescent probe, which takes 1-pyrenecarboxaldehyde-hemicyanine as a parent and has a structural general formula shown in the specification. The active inorganic sulfur species two-p

N-alkylated linear heptamethine polyenes as potent non-azole leads against Candida albicans fungal infections

In this study, eighteen heptamethine dyes were synthesised and their antifungal activities were evaluated against three clinically relevant yeast species. The eighteen dyes were placed within classes based on their core subunit i.e. 2,3,3-trimethylindolenine (5a-f), 1,1,2-trimethyl-1H-benzo[e]indole (6a-f), or 2-methylbenzothiazole (7a-f). The results presented herein imply that the three families of cyanine dyes, in particular compounds 5a-f, show high potential as selective scaffolds to treat C. albicans infections. This opens up the opportunity for further optimisation and investigation of this class compounds for potential antifungal treatment.

Preparation method and application of heptamethine indocyanine dye

The invention discloses a preparation method and application of a heptamethine indocyanine dye, and belongs to the field of polymethine indocyanine dyes and preparation thereof. The method comprises the following steps: 1) carrying out a heating reaction on raw materials containing a 2,3,3-trimethylindole derivative and a nucleophilic substituted compound under a vacuum condition to obtain an organic ammonium salt; and 2) carrying out a heating reaction on a solution containing the organic ammonium salt obtained in the step 1) and a cycloalkene derivative under a closed condition. According tothe invention, the structural formula of the heptamethine indocyanine dye is represented by a formula (I); the dye has near-infrared light absorption and fluorescence development performances and canbe used as a probe auxiliary agent; and the method is short in synthetic route, green in solvent, simple in process, free of noble metal catalysis, large in single reaction amount, high in product yield and purity, high in universality and capable of being used for synthesizing products of various structure types.

Fluorescent dye, preparation method and applications thereof

The invention belongs to the technical field of organic synthesis, and particularly relates to a fluorescent dye, a preparation method and applications thereof, wherein the fluorescent dye has a structural general formula represented by a formula I defined in the specification, X and Y are the same or different O, S, C(CH3)2 or NR6, R2 and R3 are the same or different hydrogen or functional groups, R1, R4, R5 and R6 are all functional groups, and Z is a negative ion. According to the present invention, the fluorescent dye has living cell membrane permeability, can be used for fluorescence imaging of living cell microstructures, and can obtain STED super-resolution fluorescence imaging, laser confocal imaging and other fluorescence imaging of living cells.

Molecular probes, preparation method and application thereof

The invention relates to molecular probes and a preparation method and application thereof. A series of copper ion molecular probes are prepared by halogenation reaction based on preparing of a novelheptamethine cyanine dye and ligand [bis(2-pyridylmethyl)amine]ethane-1,2-diamine. The molecular probes can accurately detect copper ions by photoacoustic imaging, have the advantages of high sensitivity, high specificity and deep tissue penetration, can simultaneously detect the copper ions in animals and plants, and have broad application prospects.

N-Alkylated 2,3,3-trimethylindolenines and 2-methylbenzothiazoles. Potential lead compounds in the fight against Saccharomyces cerevisiae infections Dedication in memory of the late Derek Bennett 17-07-1931 to 05-04-2013.

The synthesis of a variety of N-alkylated 2,3,3-trimethylindolenines and 2-methylbenzothiazoles is reported herein. Their potential as antifungal agents is evaluated by preliminary screening against Saccharomyces cerevisiae (S. cerevisiae), Schizosaccharomyces pombe (S. pombe), and Candida albicans (C. albicans). Statistical analyses illustrate a strong relationship between chain length and growth inhibition for S. cerevisiae and S. pombe (p 0.0001 in every case). Of particular interest is the activity of both sets of compounds against S. cerevisiae, as this is emerging as an opportunistic pathogen, especially in immunosuppressed and immunocompromised patients. Bioassays were set up to compare the efficacy of our range of N-alkylated compounds against classic antifungal agents; Amphotericin B and Thiabendazole.

PROCESS FOR DYE PRODUCTION

The present invention relates to a process for the production of certain compounds, especially dye compounds defined in general by Formula I: The invention provides a one-step method in which a compound of Formula II or a reactive intermediate derived in situ therefrom is reacted in situ with a compound of Formula III (optionally in the presence of a compound of Formula IV) to produce compounds of Formula I in excellent yield, and in a manner which avoids undesirable by- product formation.

NOVEL NONLINEAR CHROMOPHORES ESPECIALLY SUITED FOR USE IN ELECTRO-OPTICAL MODULATION

The present invention relates to heptamethine hemicyanine chromophores of formula (I): where R1, R2, R3, R4, R′4, R5, R′5, R6, R′6, R7, X, Y

Development and application of a near-infrared fluorescence probe for oxidative stress based on differential reactivity of linked cyanine dyes

Reactive oxygen species (ROS) operate as signaling molecules under various physiological conditions, and overproduction of ROS is involved in the pathogenesis of many diseases. Therefore, fluorescent probes for visualizing ROS are promising tools with which to uncover the molecular mechanisms of physiological and pathological processes and might also be useful for diagnosis. Here we describe a novel fluorescence probe, FOSCY-1, operating in the physiologically favorable near-infrared region. The probe consists of two differentially ROS-reactive cyanine dyes connected by a linker; reaction of the more susceptible dye with ROS releases intramolecular fluorescence quenching of the less susceptible dye. We successfully applied this probe to detect ROS produced by HL60 cells and porcine neutrophils and for imaging oxidative stress in a mouse model of peritonitis.