1394237-75-2Relevant academic research and scientific papers
An intramolecular inverse electron demand Diels-Alder approach to annulated α-carbolines
Ma, Zhiyuan,Ni, Feng,Woo, Grace H. C.,Lo, Sie-Mun,Roveto, Philip M.,Schaus, Scott E.,Snyder, John K.
, p. 829 - 840 (2012/07/17)
Intramolecular inverse electron demand cycloadditions of isatin-derived 1,2,4-triazines with acetylenic dienophiles tethered by amidations or transesterifications proceed in excellent yields to produce lactam- or lactone-fused α-carbolines. Beginning with various isatins and alkynyl dienophiles, a pilot-scale library of eighty-eight α-carbolines was prepared by using this robust methodology for biological evaluation.
