1394239-46-3Relevant academic research and scientific papers
Room temperature, palladium-mediated P-arylation of secondary phosphine oxides
Bloomfield, Aaron J.,Herzon, Seth B.
supporting information, p. 4370 - 4373 (2012/10/29)
We show that a broad range of aryl iodides are efficiently coupled with secondary phosphine oxides using 1 mol % of a catalyst formed in situ from tris(dibenzylideneacetone)dipalladium and Xantphos (1). Scalemic (S)-methylphenylphosphine oxide [(S)-2e] is shown to undergo arylation without detectable stereoerosion. The application of this method to the synthesis of novel P-chiral phosphines and PCP ligands is demonstrated.
