1394248-41-9

Upstream product

• 86-96-4 quinazoline-2,4-diol 
• 118-92-3 anthranilic acid 
• 1394248-33-9 C₁₅H₂₂N₆O 
• 104-88-1 4-chlorobenzaldehyde 
• 938514-84-2 C₁₅H₁₉ClN₄O 
• 607-68-1 2,4-dichloroquinazoline 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel 2-(2-arylmethylene)hydrazinyl- 4-aminoquinazoline derivatives as potent antitumor agents

Two series of novel 2-(2-arylmethylene)hydrazinyl-4-aminoquinazoline derivatives were synthesized and evaluated for their cytotoxicity against H-460, HT-29, HepG2 and SGC-7901 cancer cell lines in vitro. Most compounds displayed moderate to excellent activity, with IC50 values ranging from 0.015 to 4.09 μM against all tested cell lines, respectively. The most promising compound 9p (E)-2-(2-((1-(2,3-dichlorobenzyl)-1H-imidazol-2-yl)methylene) hydrazinyl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine with IC50 values of 0.031 μM, 0.015 μM, 0.53 μM and 0.58 μM, which was 4- to 224 times more active than references 10 and Iressa, had emerged as a lead for further structural modifications.