1394258-01-5

Upstream product

• 1423218-39-6 (E)-3-(1-(3-(benzyloxy)propyl)-7-bromoindolin-5-yl)-2-methylacrylic acid 
• 1423218-38-5 C₂₄H₂₈BrNO₃ 
• 1375180-28-1 1-[3-(benzyloxy)propyl]-7-bromoindoline-5-carbaldehyde 
• 459868-63-4 1-[3-(benzyloxy)propyl]indoline-5-carbaldehyde 
• 459868-64-5 1-[3-(benzyloxy)propyl]indoline 
• 26420-79-1 1-chloro-3-benzyloxypropane 
• 496-15-1 1-indoline 

Downstream Products

• 900518-68-5 C₃₀H₃₃N₃O₃ 
• 1423218-40-9 tert-butyl (2R)-(1-(1-(3-benzyloxypropyl)-7-cyanoindolin-5-yl)propane-2-yl)-N-(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate 
• 175870-34-5 tert-butyl (2R)-(1-(1-(3-benzyloxypropyl)-7-carbamoylindolin-5-yl)propan-2-yl)-N-(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate 
• 160970-54-7 silodosin 
• 459868-77-0 2,3-dihydro-1-[3-(phenylmethoxy)propyl]-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile 
• 459868-73-6 C₂₂H₂₇N₃O 
• 900518-67-4 C₂₉H₃₃BrN₂O₃ 

Relevant academic research and scientific papers

Chiral spiro monophosphine-oxazoline ligands and preparation method thereof

The invention provides chiral spiro monophosphine-oxazoline ligands as well as intermediates and a preparation method thereof. The ligands are structural compounds shown in the following formulas 1, 2and 3 and comprise racemates and optical isomers of the compounds, and m and n are integers of 0-3; X is CRR, NR, O or S; R1 and R2 are respectively and independently hydrogen, alkyl, phenyl, 1naphthyl, 2naphthyl, alkoxy and ester substituted alkyl; R is hydrogen, alkyl, substituted phenyl, substituted alkyl, alkoxy, phenyl, 1-naphthyl, 2-naphthyl, halogen, cyano, carboxyl and hydroxyl; R2 is hydrogen, alkyl, phenyl, 1-naphthyl, 2-naphthyl or alkyl substituted phenyl; M' is P(O)(R3)2 or P(R3)2; R3 is alkyl, phenyl, 1-naphthyl, 2-naphthyl, substituted phenyl, furyl or thienyl; M isOTf, COOH or COOR5; OTf is trifluoromethanesulfonic acid group; and R5 is alkyl.

Silodosin Intermediate and Preparation Method Therefor

Disclosed are a silodosin intermediate and a preparation method thereof. The silodosin intermediate has the structure shown by the formula (A). X is hydrogen or bromide and R1 is hydrogen. The formyl group may be a group having the structure sh

SILODOSIN INTERMEDIATE AND PREPARATION METHOD THEREFOR

Disclosed are a silodosin intermediate and a preparation method thereof. The silodosin intermediate has the structure shown by the formula (A). X is hydrogen or bromide and R1 is hydrogen. The formyl group may be a group having the structure shown by the formula I. R7 is an carboxyl-protecting group, and R2 is 3-hydroxypropyl or a group having the structure shown by the formula II. W is a hydroxyl-protecting group. A compound of the formula (A) according to the present invention may further be used for preparing a compound having the structure shown by the formula (D). By means of the intermediate and the preparation method therefor provided by the present invention, high-purity optically pure silodosin can be obtained, and the optical purity is above 99%.

First asymmetric synthesis of Silodosin through catalytic hydrogenation by using Ir-SIPHOX catalysts

An asymmetric synthesis of Silodosin was accomplished in high yield via catalytic hydrogenation of α,β-unsaturated carboxylic acid derivatives by using chiral catalyst Ir-SIPHOX, followed by Curtius rearrangement. Copyright