175870-34-5Relevant academic research and scientific papers
Synthesis of Silodosin by Copper-Catalysed C-C Arylation
Calogero, Francesco,Allegrini, Pietro,Attolino, Emanuele,Passarella, Daniele
, p. 6011 - 6016 (2015)
The synthesis of silodosin, an antidysuria drug, has been accomplished starting from commercially available indoline. The synthetic strategy is based on CuI-catalysed C-C arylation, regioselective cyanation, and diastereoselective reductive amination. The enantiopure compound was obtained by selective crystallisation of a diasteroisomeric mixture.
METHOD OF PREPARING ADRENERGIC ANTAGONIST
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Paragraph 0113, (2016/10/10)
PROBLEM TO BE SOLVED: To provide a method of preparing a selective adrenergic antagonist for an α-1A-adrenergic receptor and a useful intermediate thereof. SOLUTION: This invention provides an advantageous production method of a novel intermediate particularly fitted for production on an industrial scale, regarding the production of a pharmaceutical compound represented by formula (I), silodosin: 1-(3-hydroxypropyl)-5-[(2R)-({2-[2-[2-(2,2,2-trifluoroethoxy) phenoxy]ethyl}amino) propyl]indoline-7-carboxamide, or salt thereof. COPYRIGHT: (C)2015,JPOandINPIT
First asymmetric synthesis of Silodosin through catalytic hydrogenation by using Ir-SIPHOX catalysts
Yan, Pu-Cha,Zhang, Xian-Yi,Hu, Xiao-Wei,Zhang, Bin,Zhang, Xiang-Dong,Zhao, Michael,Che, Da-Qing,Li, Yuan-Qiang,Zhou, Qi-Lin
, p. 1449 - 1451 (2013/04/10)
An asymmetric synthesis of Silodosin was accomplished in high yield via catalytic hydrogenation of α,β-unsaturated carboxylic acid derivatives by using chiral catalyst Ir-SIPHOX, followed by Curtius rearrangement. Copyright
