1394290-77-7Relevant academic research and scientific papers
Copper-catalyzed nucleophilic trifluoromethylation of propargylic halides
Miyake, Yoshihiro,Ota, Shin-Ichi,Shibata, Masashi,Nakajima, Kazunari,Nishibayashi, Yoshiaki
, p. 7809 - 7811 (2013/09/02)
Reactions of propargylic halides with trifluoromethyltrimethylsilane in the presence of a catalytic amount of copper(i) thiophene-2-carboxylate (CuTC) have been found to give the corresponding trifluoromethylated products in good to high yields with a hig
A facile parallel synthesis of trifluoroethyl-substituted alkynes
Liu, Cui-Bo,Meng, Wei,Li, Feng,Wang, Shuai,Nie, Jing,Ma, Jun-An
supporting information; experimental part, p. 6227 - 6230 (2012/08/14)
Trifluoroethylation made easy: The ease of execution of the reaction (see scheme), which runs under mild conditions and without the need for additional base or ligands, allows for the rapid parallel synthesis of a broad variety of trifluoroethylated alkynes. Both experimental and theoretical analyses indicate that the trifluoromethylcarbene could undergo concerted insertion into the Csp-H bond of the alkyne. Copyright
