1394387-97-3

Basic information

• Product Name: N-((3-isopropylisoxazol-5-yl)methyl)-2-(4-phenylpiperidin-1-yl)ethanamine
• Synonyms: N-((3-isopropylisoxazol-5-yl)methyl)-2-(4-phenylpiperidin-1-yl)ethanamine
• CAS NO: 1394387-97-3
• Molecular Weight: 327.47
• Mol File: 1394387-97-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-((3-isopropylisoxazol-5-yl)methyl)-2-(4-phenylpiperidin-1-yl)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-((3-isopropylisoxazol-5-yl)methyl)-2-(4-phenylpiperidin-1-yl)ethanamine(1394387-97-3)
• EPA Substance Registry System: N-((3-isopropylisoxazol-5-yl)methyl)-2-(4-phenylpiperidin-1-yl)ethanamine(1394387-97-3)

Safety Data

• Hazardous Substances Data: 1394387-97-3(Hazardous Substances Data)

Upstream product

• 108-86-1 bromobenzene 
• 186347-72-8 4-phenyl-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 41914-43-6 2-(4-phenylpiperidin-1-yl)ethanamine 
• 771-99-3 4-phenylpiperidine 
• 123387-49-5 tert-butyl 4-phenylpiperidine-1-carboxylate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 

Relevant articles and documents

Synthesis and biological evaluation of 1-(isoxazol-5-ylmethylaminoethyl)-4- phenyl tetrahydropyridine and piperidine derivatives as potent T-type calcium channel blockers with antinociceptive effect in a neuropathic pain model

New tetrahydropyridinyl and piperidinyl ethylamine derivatives were designed with hypothetical mapping on pharmacophore model generated from ligand-based virtual screening. The designed compounds were synthesized, and their inhibitory activities on T-type calcium channel were assayed using FDSS and patch-clamp assay. Among them, compounds 7b and 10b showed potent T-type calcium current blocking activity against Cav3.1 (α 1G) and Cav3.2 (α1H) channel simultaneously. With hERG and pharmacokinetics studies, compounds 7b and 10b were evaluated for the antinociceptive effect on rat model of neuropathic pain. They were significantly effective in decreasing the pain responses to mechanical and cold allodynia induced by spinal nerve ligation. These results suggest that modulation of α1G and α1H subtype T-type calcium channels may provide a promising approach for the treatment of neuropathic pain.