1394389-58-2Relevant academic research and scientific papers
Synthesis of new pyrimidinylthio-substituted 1,3,4-oxa(thia)diazoles and 1,2,4-triazoles
Burbuliene, Milda M.,Simkus, Aliona,Vainilavicius, Povilas
, p. 403 - 411 (2012/10/29)
Novel 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazole-3-thiones bearing the pyrimidinylthio-moiety were synthesized by cyclization of a substituted-thiosemicarbazide precursor under different conditions. The thiosemicarbazide intermediates were easily accessed from reaction of biologically active 2-(4,6-dimethylpyrimidin-2-ylthio)acetohydrazide and 2-(2-dimethylamino-6-methyl pyrimidin-4-ylthio)acetohydrazide with cyclohexyl or phenyl isothiocyanate. The compounds are characterized by 1H, 13C NMR, IR spectroscopy and analytical data.
