139460-76-7

Upstream product

• 26156-84-3 N-tritylpyridinium tetrafluoroborate 
• 139427-74-0 (S)-2-Hydroxy-2-[(3R,4S,5R)-3-((R)-2-hydroxy-1-methyl-ethyl)-2,2,4-trimethyl-[1,2]oxasilolan-5-yl]-N-methoxy-N-methyl-acetamide 
• 103668-54-8 (3S,4R)-3-((S)-2-Benzyloxy-1-methyl-ethyl)-2,2,4-trimethyl-[1,2]oxasilolane 
• 139427-73-9 (E)-(S)-4-((3S,4R)-2,2,4-Trimethyl-[1,2]oxasilolan-3-yl)-pent-2-enoic acid methoxy-methyl-amide 
• 139427-68-2 (S)-2-((3S,4R)-2,2,4-Trimethyl-[1,2]oxasilolan-3-yl)-propan-1-ol 

Downstream Products

• 139427-82-0 (3R,4R,6R,8S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-2,6,8-trimethyl-9-trityloxy-non-1-en-5-one 
• 139427-77-3 (4S,5R,6R,8S)-5-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-2,6,8-trimethyl-9-trityloxy-non-1-en-3-one 
• 139427-81-9 (3R,4S,5R,6R,8S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-2,6,8-trimethyl-9-trityloxy-non-1-en-5-ol 
• 139427-75-1 (2S,3R,4R,6S)-3-Hydroxy-2-methoxy-4,6-dimethyl-7-trityloxy-heptanoic acid methoxy-methyl-amide 
• 139460-75-6 (S)-2,N-Dimethoxy-N-methyl-2-[(3R,4S,5R)-2,2,4-trimethyl-3-((R)-1-methyl-2-trityloxy-ethyl)-[1,2]oxasilolan-5-yl]-acetamide 

Relevant academic research and scientific papers

Siloxanes: Versatile Templates for Acyclic Stereocontrol. Synthesis of the C27-C33 Segment of Rapamycin

Five-membered siloxane rings may be employed to relay asymmetry along an acyclic chain in an efficient manner.Application of this method to the synthesis of the C27-C33 segment of the immunosuppressant rapamycin is reported.