Siloxanes: Versatile Templates for Acyclic Stereocontrol. Synthesis of the C27-C33 Segment of Rapamycin

DOI: 10.1021/jo00032a007

Source and publish data:

Journal of Organic Chemistry p. 1643 - 1645 (1992)

Update date:2022-08-04

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Authors:

Hale, Michael R.

Hoveyda, Amir H.

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Article abstract of DOI:10.1021/jo00032a007

Five-membered siloxane rings may be employed to relay asymmetry along an acyclic chain in an efficient manner.Application of this method to the synthesis of the C27-C33 segment of the immunosuppressant rapamycin is reported.

Full text of DOI:10.1021/jo00032a007

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