1394826-22-2

Upstream product

• 768-92-3 1-adamantyl fluoride 
• 78704-49-1 1-(4-chlorophenyl)-2-trimethylsilylacetylene 
• 15897-81-1 adamantane-2-carboxylic acid 
• 1394826-53-9 1-((4-chlorophenyl)ethynyl)-1λ³-benzo[d][1,2]iodaoxol-3(1H)-one 

Relevant academic research and scientific papers

Aluminum-Catalyzed Cross-Coupling of Silylalkynes with Aliphatic C-F Bonds

We report the generation of aliphatic and benzylic acetylenes via reaction of primary, secondary, and tertiary aliphatic fluorides with various trimethylsilyl acetylides. These reactions are catalyzed by Al and B Lewis acids, most effectively by the extre

Silver-catalyzed decarboxylative alkynylation of aliphatic carboxylic acids in aqueous solution

C(sp3)-C(sp) bond formations are of immense interest in chemistry and material sciences. We report herein a convenient, radical-mediated and catalytic method for C(sp3)-C(sp) cross-coupling. Thus, with AgNO3 as the catalyst and K2S2O8 as the oxidant, various aliphatic carboxylic acids underwent decarboxylative alkynylation with commercially available ethynylbenziodoxolones in aqueous solution under mild conditions. This site-specific alkynylation is not only general and efficient but also functional group compatible. In addition, it exhibits remarkable chemo- and stereoselectivity.