139488-44-1

Basic information

• Product Name: 2-mercapto-1-(4-methoxyphenyl)ethanone
• CAS NO: 139488-44-1
• Molecular Formula: C₉H₁₀O₂S
• Molecular Weight: 182.24
• Mol File: 139488-44-1.mol
• Article Data: 7

Chemical Properties

• Refractive Index: 1.552
• CAS DataBase Reference: 2-mercapto-1-(4-methoxyphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-mercapto-1-(4-methoxyphenyl)ethanone(139488-44-1)
• EPA Substance Registry System: 2-mercapto-1-(4-methoxyphenyl)ethanone(139488-44-1)

Safety Data

• Hazardous Substances Data: 139488-44-1(Hazardous Substances Data)

Upstream product

• 119267-77-5 S-acetyl-2-mercapto-4’-methoxyacetophenone 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 

Downstream Products

• 60755-22-8 1-(4-methoxyphenyl)-4-phenyl-1,4-butanedione 
• 149109-18-2 6-acetoxy-1-(4-methoxyphenyl)hexan-1-one 
• 805240-60-2 6-hydroxy-1-(4-methoxyphenyl)hexan-1-one 
• 62170-25-6 1-(4-methoxyphenyl)octan-1-one 
• 61022-41-1 1-(4-methoxyphenyl)-5-phenylpentan-1-one 
• 7347-70-8 N-[4-(4-methoxy-phenyl)-4-oxo-butyl]-phthalimide 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 24188-99-6 2-cyclopentyl-1-(4-methoxyphenyl)ethan-1-one 
• 616226-79-0 (5-oxo-5-(4-methoxyphenyl)-pentyl)-carbamic acid tert-butyl ester 
• 1039453-76-3 N-ethyl S-2-(4-methoxyphenyl)-2-oxoethyl thiocarbamate 
• 1039453-67-2 N-ethyl S-2-(4-methoxyphenyl)-2-oxoethyl dithiocarbamate 

Relevant articles and documents

Synthesis of Unsymmetrical 1,4-Dicarbonyl Compounds by Photocatalytic Oxidative Radical Additions

Herein we report a photocatalytic oxidative radical addition reaction for the synthesis of unsymmetrical 1,4-dicarbonyl compounds. This reaction utilizes a desulfurization process to generate electrophilic radicals, which add to α-halogenated alkenes and undergo further oxidation to deliver 1,4-dicarbonyl compounds. This mild and highly efficient method provides a valuable alternative to known strategies.

Site-Selective and Enantioselective α,β,γ-Functionalization of 5-Alkylidenefuran-2(5 H)-ones: A Route to Polycyclic γ-Lactones

A new strategy for a direct α,β,γ-functionalization of the γ-lactone framework in the corresponding 5-alkylidenefuran-2(5H)-ones is reported. The developed approach is based on a stereocontrolled cascade reaction with 2-mercaptocarbonyl compounds proceedi

Trithiocarbonates as a novel class of HDAC inhibitors: SAR studies, isoenzyme selectivity, and pharmacolozgical profiles

Inhibitors of histone deacetylases (HDAC) are currently developed for the treatment of cancer. These include compounds with a sulfur containing head group like depsipeptide, alkylthiols, thiocarboxylates, and trithiocarbonates with a carbonyl group in the α-position. In the present investigation, we report on the synthesis and comprehensive SAR analysis of HDAC inhibitors bearing a tri- or dithiocarbonate motif. Such trithiocarbonates are readily accessible from either preformed or in situ prepared α-halogenated methylaryl ketones. A HDAC isotype selectivity and a substrate competitive mode-of-action is shown for defined analogues. Exploration of the head group showed the necessity of the dithio-α-carbonyl motif for potent HDAC inhibition. Highly potent, substrate competitive HDAC6 selective inhibitors were identified (12ac:IC50 = 65 nM and Ki = 110 nM). Trithiocarbonate analogues with an aminoquinoline-substituted pyridinyl-thienoacetyl cap demonstrate a cytotoxicity profile and potency comparable to that of suberoylanilide hydroxamic acid (SAHA) as an approved cancer drug.