616226-79-0Relevant academic research and scientific papers
Intermolecular Phosphite-Mediated Radical Desulfurative Alkene Alkylation Using Thiols
Lopp, John M.,Schmidt, Valerie A.
, p. 8031 - 8036 (2019/10/19)
We report herein the development of a S atom transfer process using triethyl phosphite as the S atom acceptor that allows thiols to serve as precursors of C-centered radicals. A range of functionalized and electronically unbiased alkenes including those containing common heteroatom-based functional groups readily participate in this reductive coupling. This process is driven by the exchange of relatively weak S-H and C-S bonds of aliphatic thiols for C-H, C-C, and S-P bonds of the products formed.
Phosphinates as new electrophilic partners for cross-coupling reactions
Guo, Jun,Harling, John D.,Steel, Patrick G.,Woods, Tom M.
supporting information; experimental part, p. 4053 - 4058 (2009/06/28)
The use of enol phosphinates as electrophiles for cross-coupling reactions has been explored. Both boronic acids (Suzuki-Miyaura reaction) and stannanes (Stille reaction) couple efficiently with lactam derived phosphinates. The 2008 Royal Society of Chemi
A One-Pot Process for the Enantioselective Synthesis of Amines via Reductive Amination under Transfer Hydrogenation Conditions
Williams, Glynn D.,Pike, Richard A.,Wade, Charles E.,Wills, Martin
, p. 4227 - 4230 (2007/10/03)
(Equation presented) Cyclic amines may be prepared via a sequence of deprotection followed by intramolecular reductive amination of t-Boc-protected amino ketones under asymmetric transfer hydrogenation conditions. In cases where the corresponding imine reaction proceeds with high enantioselectivity, this is reflected in the one-step process.
