139489-49-9Relevant academic research and scientific papers
Synthesis of the 2-Amino-4-phosphonobutanoic Acid Analogues (E)- and (Z)-2-Amino-2,3-methano-4-phosphonobutanoic Acid and Their Evaluation as Inhibitors of Hippocampal Excitatory Neurotransmission
Kroona, Heather B.,Peterson, Nancy L.,Koerner, James F.,Johnson, Rodney L.
, p. 1692 - 1699 (1991)
The cyclopropyl compounds (Z)- and (E)-2-amino-2,3-methano-4-phosphonobutanoic acid, 5 and 6, respectively, were prepared as constrained analogues of 2-amino-4-phosphonobutanoic acid (AP4), a selective glutamate receptor ligand.A Horner-Emmons reaction of
