1394940-72-7

Upstream product

• 102560-84-9 4-hydroxy-N-tritylbutanamide 
• 621-84-1 O-benzyl carbamate 
• 4235-89-6 tris(4-(tert-butyl)phenyl) phosphite 
• 159492-89-4 4-oxo-N-tritylbutanamide 
• 1195771-44-8 methyl 4-oxo-4-(tritylamino)butanoate 

Downstream Products

• 1394940-92-1 C₄₃H₅₉N₄O₁₀P 
• 1394940-76-1 C₃₂H₄₁N₂O₆P 
• 1394940-96-5 C₄₃H₄₉N₂O₄P 
• 1394940-80-7 C₅₇H₆₆N₃O₇P 
• 1394940-88-5 C₆₆H₈₁N₄O₁₀P 
• 1394941-00-4 C₄₉H₆₀N₃O₅P 
• 1394940-84-1 C₃₈H₅₂N₃O₇P 

Relevant academic research and scientific papers

The development of first Staphylococcus aureus SplB protease inhibitors: Phosphonic analogues of glutamine

Produced by Staphylococcus aureus, SplB belongs to the chymotrypsin-like serine protease family. Since the biological role of SplB protease is unknown, the design and application of its specific inhibitors may help to reveal the function of this enzyme. Until now no SplB inhibitors have been reported. Herein, we present the design and synthesis of novel α-aminophosphonic analogues of glutamine, as well as their peptidyl derivatives. The inhibitory effects of these compounds towards the newly discovered SplB serine protease from S. aureus are characterized. We have also investigated the influence of aromatic ester substituents on inhibitory potency towards SplB. One of the compounds - Cbz-Glu-Leu-GlnP(OC6H4-4-O-CH 3)2 - displayed an apparent second-order inhibition rate value of 1400 M-1 s-1.