1395074-19-7

Basic information

• Product Name: 2-isobutylamino-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(S)-1-(3-cbloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide
• CAS NO: 1395074-19-7
• Molecular Weight: 421.902
• Mol File: 1395074-19-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-isobutylamino-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(S)-1-(3-cbloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-isobutylamino-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(S)-1-(3-cbloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide(1395074-19-7)
• EPA Substance Registry System: 2-isobutylamino-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(S)-1-(3-cbloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide(1395074-19-7)

Safety Data

• Hazardous Substances Data: 1395074-19-7(Hazardous Substances Data)

Upstream product

• 871726-72-6 4-((dimethylamino)methylene)-3-oxopiperidine-1-carboxylic acid tert-butyl ester 
• 98977-36-7 3-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 496856-52-1 (S)-2-amino-2-(3-chloro-4-fluorophenyl)ethan-1-ol 
• 1610518-05-2 C₁₁H₁₈N₄ 
• 530-62-1 1,1'-carbonyldiimidazole 

Relevant articles and documents

Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2

The discovery and optimization of a series of tetrahydropyridopyrimidine based extracellular signal-regulated kinase (Erks) inhibitors discovered via HTS and structure based drug design is reported. The compounds demonstrate potent and selective inhibition of Erk2 and knockdown of phospho-RSK levels in HepG2 cells and tumor xenografts.

SERINE/THREONINE KINASE INHIBITORS

Compounds having the formula I wherein Z, Z1 Z2 Z3, R3a, R3b and Rb and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperprolife