496856-52-1

Usage

Uses

Used in Pharmaceutical Industry:
(2S)-2-AMINO-2-(3-CHLORO-4-FLUOROPHENYL)ETHAN-1-OL is used as a chemical intermediate for the synthesis of new drugs and medications. Its unique structure, including the 3-chloro-4-fluorophenyl group, may contribute to the development of pharmaceuticals with novel mechanisms of action or improved therapeutic profiles. Further research and testing are required to fully understand and harness its potential in drug discovery and medicinal chemistry.

Upstream product

• 1312718-99-2 (rs)-N-(2-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-fluorophenyl)ethylidene)-2-methylpropane-2-sulfinamide 
• 1312719-11-1 (Rs,1S)-N-(2-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-fluorophenyl)ethyl)-2-methylpropane-2-sulfinamide 
• 1312719-21-3 (S)-2-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-fluorophenyl)ethanamine 
• 1312718-88-9 2-(tert-butyldimethylsilyloxy)-1-(3-chloro-4-fluorophenyl)ethanone 
• 60811-21-4 1-bromo-3-chloro-4-fluorobenzene 

Downstream Products

• 1395074-42-6 2-(2-methyl-pyridin-4-ylamino)-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(S)-1-(3-chloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide 
• 1395074-63-1 2-(1-methyl-1H-pyrazol-4-ylamino)-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(S)-1-(3-chloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide 
• 1395074-32-4 2-acetylamino-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(S)-1-(3-chloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide 
• 1395074-19-7 2-isobutylamino-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(S)-1-(3-cbloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide 
• 1395074-21-1 2-(3,5-dimethyl-isoxazol-4-ylamino)-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(S)-1-(3-chloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide 
• 1395074-23-3 2-(4-fluoro-phenylamino)-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(s)-1-(3-chloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide 
• 1395074-77-7 2-((1S,3S)-3-hydroxy-cyclopentylamino)-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(S)-1-(3-chloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide 
• 1395074-05-1 2-tert-butylamino-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(S)-1-(3-chloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide 
• 1395072-70-4 C₂₁H₂₅ClFN₅O₃ 
• 1395074-03-9 2-cyclopentylamino-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(S)-1-(3-chloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide 
• 1395073-98-9 2-(2-hydroxy-ethylamino)-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(S)-1-(3-chloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide 
• 1395076-96-6 2-ethylamino-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(S)-1-(3-chloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide 
• 1395074-17-5 2-methylamino-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid [(S)-1-(3-chloro-4-fluoro-phenyl)-2-hydroxy-ethyl]-amide 

Relevant academic research and scientific papers

A general asymmetric synthesis of phenylglycinols

Hydride reduction and deprotection of siloxymethyl sulfinimines 2 reliably furnished chiral phenylglycinols 1 or 10 in high overall yield and enantiomeric purity.