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1395172-07-2

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1395172-07-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1395172-07-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,9,5,1,7 and 2 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1395172-07:
(9*1)+(8*3)+(7*9)+(6*5)+(5*1)+(4*7)+(3*2)+(2*0)+(1*7)=172
172 % 10 = 2
So 1395172-07-2 is a valid CAS Registry Number.

1395172-07-2Downstream Products

1395172-07-2Relevant academic research and scientific papers

Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors

Kumar, D. Vijay,Hoarau, Christophe,Bursavich, Matthew,Slattum, Paul,Gerrish, David,Yager, Kraig,Saunders, Michael,Shenderovich, Mark,Roth, Bruce L.,McKinnon, Rena,Chan, Ashley,Cimbora, Daniel M.,Bradford, Chad,Reeves, Leslie,Patton, Scott,Papac, Damon I.,Williams, Brandi L.,Carlson, Robert O.

, p. 4377 - 4385 (2012/08/07)

Efforts to optimize biological activity, novelty, selectivity and oral bioavailability of Mps1 inhibitors, from a purine based lead MPI-0479605, are described in this Letter. Mps1 biochemical activity and cytotoxicity in HCT-116 cell line were improved. On-target activity confirmation via mechanism based G2/M escape assay was demonstrated. Physico-chemical and ADME properties were optimized to improve oral bioavailability in mouse.

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