581-00-0

Basic information

• Product Name: 2-methyl-4-morpholin-4-ylaniline
• Synonyms: 2-methyl-4-morpholin-4-ylaniline;2-METHYL-4-(4-MORPHOLINYL)BENZENAMINE;2-METHYL-4-MORPHOLINOBENZENAMINE;BenzenaMine, 2-Methyl-4-(4-Morpholinyl)-;2-Methyl-4-Morpholinoaniline;2-METHYL-4-MORPHOLIN-4-YLANILINE(RS20015346)
• CAS NO: 581-00-0
• Molecular Formula: C₁₁H₁₆N₂O
• Molecular Weight: 192.26
• Mol File: 581-00-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 393.3±42.0 °C(Predicted)
• Appearance: Yellow to brown/Crystalline Powder
• Density: 1.122±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 6.87±0.40(Predicted)
• CAS DataBase Reference: 2-methyl-4-morpholin-4-ylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-4-morpholin-4-ylaniline(581-00-0)
• EPA Substance Registry System: 2-methyl-4-morpholin-4-ylaniline(581-00-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 581-00-0(Hazardous Substances Data)

Usage

General Description

2-methyl-4-morpholin-4-ylaniline is a chemical compound with the molecular formula C12H18N2O. It is an aromatic amine derivative with a morpholine ring and a methyl group attached to the benzene ring. 2-methyl-4-morpholin-4-ylaniline is commonly used as an intermediate in the synthesis of pharmaceuticals, dyes, and other organic compounds. It is also used as a precursor in the production of various agrochemicals and as a reagent in organic synthesis. 2-methyl-4-morpholin-4-ylaniline is known to be toxic and should be handled with care in a laboratory setting.

Upstream product

• 220679-09-4 4-(3-methyl-4-nitrophenyl)morpholine 
• 446-33-3 5-Fluoro-2-nitrotoluene 

Downstream Products

• 1395172-03-8 C₂₉H₄₀N₈O₄ 
• 1395172-00-5 C₂₇H₃₇N₇O₃ 
• 1246529-64-5 4-[(2-{[2-methyl-4-(morpholin-4-yl)phenyl]amino}-9H-purin-6-yl)amino]cyclohexanol 
• 1246529-35-0 ethyl 4-[(2-{[2-methyl-4-(morpholin-4-yl)phenyl]amino}-9H-purin-6-yl)amino]piperidine-1-caxboxylate 
• 1383810-38-5 C₂₁H₂₈N₈O 
• 1383810-36-3 C₂₀H₂₅N₇O₂ 
• 1395172-07-2 C₂₅H₃₃N₇O₃ 
• 1246529-78-1 6-(cyclohexyloxy)-N-[2-methyl-4-(morpholin-4-yl)phenyl]-9H-purin-2-amine 
• 1383810-33-0 C₂₃H₃₂N₈O 
• 1395172-17-4 C₃₁H₄₄N₈O₃ 
• 1246529-94-1 N₂-[2-methyl-4-(morpholin-4-yl)phenyl]-N₆-[4-(morpholin-4-yl)cyclohexyl]-9H-purine-2,6-diamine 
• 1246529-32-7 MPI-0479605 
• 1383810-31-8 C₂₃H₃₀N₆O 

Relevant articles and documents

A class of FLT3 kinase inhibitors, preparation and application thereof

The invention relates to a class of FLT3 kinase inhibitors, preparation and application thereof, wherein specifically the compound has a structure represented by a formula (I), and all groups and substituents are defined in the specification. The invention also discloses a preparation method of the compound, and application of the compound in inhibition of FLT3.

Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors

Efforts to optimize biological activity, novelty, selectivity and oral bioavailability of Mps1 inhibitors, from a purine based lead MPI-0479605, are described in this Letter. Mps1 biochemical activity and cytotoxicity in HCT-116 cell line were improved. On-target activity confirmation via mechanism based G2/M escape assay was demonstrated. Physico-chemical and ADME properties were optimized to improve oral bioavailability in mouse.

MORPHOLINYLANILINOQUINAZO- LINE DERIVATIVES FOR USE AS ANTIVIRAL AGENTS

Compounds of formula (Ia) are found to be active in inhibiting replication of flaviviridae viruses, wherein R1, R2, R3 and R4 are as defined in the claims.