139546-24-0

Upstream product

• 14645-49-9 methyl 2,3-anhydro-5-O-benzyl-α-D-lyxofuranoside 
• 53081-34-8 methyl 2-O-mesyl-α-D-xylofuranoside 
• 7045-39-8 methyl 3,5-O-isopropylidene-2-O-mesyl-α-D-xylofuranoside 
• 7045-40-1 Methyl 3,5-O-Isopropylidene-α-D-xylofuranoside 
• 1824-96-0 methyl xylofuranoside 
• 532-20-7 D-xylofuranose 
• 14980-09-7 methyl 5-O-benzyl-3-fluoro-3-deoxy-α-D-arabino-furanoside 

Downstream Products

• 1615696-39-3 C₂₁H₂₃FO₅ 
• 1615696-40-6 C₁₇H₁₉FO₇ 
• 1615696-41-7 C₂₀H₁₉ClFN₅O₅ 
• 1615696-42-8 (2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-ethoxy-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate 
• 1615696-44-0 (2S)-cyclohexyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-ethoxy-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(3-chloro-4-fluorophenoxy)phosphoryl)amino)propanoate 
• 1615696-45-1 (2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-ethoxy-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate 
• 1615696-46-2 (2S)-cyclohexyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-ethoxy-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate 
• 1615696-47-3 C₂₂H₂₃FO₆ 
• 1615696-48-4 C₂₅H₂₃ClFN₅O₄ 
• 1615696-49-5 C₄₅H₃₉ClFN₅O₅ 
• 1615696-50-8 C₃₁H₃₀FN₅O₅ 
• 1615696-52-0 (2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate 
• 1615696-51-9 C₄₅H₄₉ClFN₆O₉P 
• 1615696-53-1 C₄₆H₄₈ClF₂N₆O₉P 

Relevant academic research and scientific papers

Fluoroglycolactone synthesis method

The invention discloses a synthesis method of fluoro sugar lactone. According to the method, D-xylose is taken as a starting raw material, hydroxyl is protected to synthesize a lactonide compound intermediate, and then the fluoroglycolactone is obtained through the steps of stereo conversion of sugar cyclic alcohol, benzyl addition, methyl glycoside removal, hydroxyl oxidation and the like. The raw materials adopted by the synthesis method are simple, cheap and easy to obtain, each synthesis step is mild in condition, the treatment process is simple, the yield is relatively high, and new raw materials and synthesis ways are provided for design of fluorine-containing bioactive molecules.

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Disclosed herein are nucleosides, nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Filoviridae virus infection with one or more nucleosides and/or nucleotide analogs.

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Coronaviridae virus, a Togaviridae virus, a Hepeviridae virus and/or a Bunyaviridae virus infection with one or more nucleosides, nucleotides and nucleotide analogs.

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Picornavirus and/or Flaviviridae infection with one or more nucleosides, nucleotides and nucleotide analogs.

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.