139547-12-9Relevant articles and documents
SYNTHESIS AND PROPERTIES OF 2-TRIFLUOROMETHYL-SUBSTITUTED 4-PENTENOIC AND 3,4-PENTADIENOIC ACIDS AND THEIR ESTERS
Andreev, V. G.,Kolomiets, A. F.,Fokin, A. V.
, p. 2447 - 2451 (1991)
The hydrolysis of the acid fluorides of 2-fluorocarbonyl(methoxycarbonyl)-2-trifluoromethyl-4-pentenoic acids (I) and (II), and of 2-fluorocarbonyl(methoxycarbonyl)-2-trifluoromethyl-3,4-pentadienoic acids (III) and (IV) gave, under mild conditions, 2-trifluoromethyl-4-pentenoic acid (V) and 2-trifluoromethyl-3,4-pentadienoic acid (VII) or their methyl esters (VI) and (VIII).The reactivity of these compounds was studied.
A one-step photocatalytic synthesis of 2-(trifluoromethyl)butyrolactones
Reineke, Ninja,Zaidi, Naveed A.,Mitra, Manju,O'Hagan, David,Batsanov, Andrei S.,Howard, Judith A. K.,Naumov, Dmitri Y.
, p. 147 - 150 (2007/10/03)
An efficient one-step procedure is described for the synthesis of 2-(trifluoromethyl)butyrolactone 1 and 4-substituted 2-(trifluoromethyl)butyrolactones by the photocatalytic conjugate addition of primary and secondary alcohols to 2-(trifluoromethyl)acrylic acid 6. With the exception of methanol, the reactions are conducted without a photosensitiser. The diastereoisomers of compounds 8 and 10 were separable by chromatography and their relative configurations were established unambiguously by X-ray analyses of suitable crystals.