1395473-67-2

Basic information

• Product Name: 4-((2R,3S)-3-acetyl-6-chloro-1,2,3,4-tetrahydroquinolin-2-yl)-benzonitrile
• Synonyms: 4-((2R,3S)-3-acetyl-6-chloro-1,2,3,4-tetrahydroquinolin-2-yl)-benzonitrile
• CAS NO: 1395473-67-2
• Molecular Weight: 310.783
• Mol File: 1395473-67-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-((2R,3S)-3-acetyl-6-chloro-1,2,3,4-tetrahydroquinolin-2-yl)-benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((2R,3S)-3-acetyl-6-chloro-1,2,3,4-tetrahydroquinolin-2-yl)-benzonitrile(1395473-67-2)
• EPA Substance Registry System: 4-((2R,3S)-3-acetyl-6-chloro-1,2,3,4-tetrahydroquinolin-2-yl)-benzonitrile(1395473-67-2)

Safety Data

• Hazardous Substances Data: 1395473-67-2(Hazardous Substances Data)

Upstream product

• 951234-87-0 4-(3-oxobut-1-yn-1-yl)benzonitrile 
• 20028-53-9 2-amino-5-chlorobenzaldehyde 

Relevant articles and documents

Highly regio-, diastereo- and enantioselective one-pot gold/chiral Bronsted acid-catalysed cascade synthesis of bioactive diversely substituted tetrahydroquinolines

One-pot sequential asymmetric reactions of aminobenzaldehydes or aminophenones with alkynes catalysed by a gold(i)/Bronsted acid cooperative system are reported. This process provides a highly efficient method for the synthesis of optically active tetrahydroquinolines, with one or two chiral centres at different positions as well as highly divergent functional groups, in good to excellent yields and with high regio-, diastereo- and enantioselectivities. A preliminary study on the effect of stereochemistry on biological activity suggests a potential application of these optically active tetrahydroquinolines in drug discovery processes.