951234-87-0

Basic information

• Product Name: 4-(3-oxobut-1-yn-1-yl)benzonitrile
• Synonyms: 4-(3-oxobut-1-yn-1-yl)benzonitrile
• CAS NO: 951234-87-0
• Molecular Weight: 169.183
• Mol File: 951234-87-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-(3-oxobut-1-yn-1-yl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-oxobut-1-yn-1-yl)benzonitrile(951234-87-0)
• EPA Substance Registry System: 4-(3-oxobut-1-yn-1-yl)benzonitrile(951234-87-0)

Safety Data

• Hazardous Substances Data: 951234-87-0(Hazardous Substances Data)

Upstream product

• 3032-92-6 4-cyanophenylacetylene 
• 141-78-6 ethyl acetate 
• 893748-15-7 4-(3-hydroxybut-1-yn-1-yl)benzonitrile 

Downstream Products

• 893748-15-7 4-(3-hydroxybut-1-yn-1-yl)benzonitrile 
• 1395473-67-2 4-((2R,3S)-3-acetyl-6-chloro-1,2,3,4-tetrahydroquinolin-2-yl)-benzonitrile 

Relevant articles and documents

Lewis-base-catalysed selective reductions of ynones with a mild hydride donor

Ynones are efficiently reduced with a mild hydride donor in the presence of a catalytic amount of nucleophilic phosphines. The reactions are selective 1,2-reductions that give propargyl alcohols in yields of up to 96%. It is proposed that success in these reactions depends on the activation of ynones by a Lewis base catalyst. A protic additive plays a key role in suppressing the undesired reaction pathways and accelerating the 1,2-reductions.

Phosphane-Catalyzed [3+3] Annulation of C,N-Cyclic Azomethine Imines with Ynones: A Practical Method for Tricyclic Dinitrogen-Fused Heterocycles

A phosphane-catalyzed [3+3] annulation of azomethine imines with ynones has been developed. Under mild reaction conditions, the reaction proceeds smoothly to afford tricyclic dinitrogen-fused heterocyclic compounds in moderate to excellent yields with moderate to excellent stereoselectivies. Using a chiral phosphine as the catalyst, the reaction could work to give the cycloadduct in moderate yield with moderate enantioselectivity. (Figure presented.) .