13956-50-8Relevant articles and documents
Convenient synthesis and application of versatile nucleic acid lipid membrane anchors in the assembly and fusion of liposomes
Ries, Oliver,L?ffler, Philipp M. G.,Vogel, Stefan
supporting information, p. 9673 - 9680 (2015/09/28)
Hydrophobic moieties like lipid membrane anchors are highly demanded modifications for nucleic acid oligomers. Membrane-anchor modified oligonucleotides are applicable in biomedicine leading to new delivery strategies as well as in biophysical investigations towards the assembly and fusion of liposomes or the construction of DNA origami structures. We present herein the synthesis and applications of versatile lipid membrane anchor building blocks suitable for solid-supported oligonucleotide synthesis. These are readily synthesized in bulk in five to seven steps from commercially available precursors and can be incorporated at any position within an oligonucleotide without significantly altering the duplex stability and structure as was proven by thermal denaturation experiments and circular dichroism. Furthermore, their applicability could be demonstrated by the assembly and fusion of liposomes mediated by lipid-modified oligonucleotides.
Chemical constituents of aquatic fern Azolla nilotica
Arai, Yoko,Nakagawa, Tomomi,Hitosugi, Mari,Shiojima, Kenji,Ageta, Hiroyuki,Abdel-Halim, Osama Basher
, p. 471 - 474 (2007/10/03)
Two new components, (24R)-6β-hydroxy-24-ethyl-cholest-4-en-3-one and phytyl-3,7,11,15-tetramethyl-2-hexadecanenate were isolated from the whole plants of aquatic fern Azolla nilotica. Their structures were established by spectroscopic techniques and chemical correlation. Some typical triterpenoids of ferns were also detected.
