139577-60-9

Upstream product

• 136527-53-2 methyl 4-(5-acetoxypent-1-en-2-yl)benzoate 
• 139577-56-3 methyl 4-(6-carboethoxy-6-cyanohex-2-en-2-yl)benzoate 
• 139577-58-5 4-<5-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-pent-2-en-2-yl>benzoic acid 
• 139577-57-4 methyl 4-<5-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-pent-2-en-2-yl>benzoate 
• 139577-55-2 methyl 4-(5-iodopent-2-en-2-yl)benzoate 
• 139577-54-1 methyl 4-(5-iodopent-1-en-2-yl)benzoate 
• 136527-54-3 methyl 4-(5-hydroxypent-1-en-2-yl)benzoate 
• 139577-59-6 dimethyl N-<4-<5-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-pent-2-en-2-yl>benzoyl>-L-glutamate 

Relevant academic research and scientific papers

Synthesis of 10-substituted "open-chain" analogues of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF, lometrexol)

Several novel and very potent folate antimetabolites, structurally based upon our previously described "open-chain" version of DDATHF but carrying 1-carbon substituents in the 10-position, have been synthesized. A key synthetic sequence involving a pallad