136527-54-3

Upstream product

• 136527-53-2 methyl 4-(5-acetoxypent-1-en-2-yl)benzoate 

Downstream Products

• 554-68-7 triethylamine hydrochloride 
• 136527-55-4 methyl 4-(5-methylsulfonyloxypent-1-en-2-yl)benzoate 
• 136527-61-2 dimethyl N-<4-<5-(2,4-diamino-6(1H)-pyrimidinone-5-yl)-pent-1-hydroxy-2-yl>benzoyl>-L-glutamate 
• 136527-62-3 N-<4-<5-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-pent-1-hydroxy-2-yl>benzoyl>-L-glutamic acid 
• 139577-59-6 dimethyl N-<4-<5-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-pent-2-en-2-yl>benzoyl>-L-glutamate 
• 139577-61-0 dimethyl N-<4-<5-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-pent-2-yl>benzoyl>-L-glutamate 
• 136548-01-1 dimethyl N-<4-<5-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-pent-1-en-2-yl>benzoyl>-L-glutamate 
• 139577-60-9 N-<4-<5-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-pent-2-en-2-yl>benzoyl>-L-glutamic acid 
• 139577-65-4 N-<4-<5-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-pent-2-yl>benzoyl>-L-glutamic acid 
• 136527-59-8 N-<4-<5-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-pent-1-en-2-yl>benzoyl>-L-glutamic acid 
• 139577-57-4 methyl 4-<5-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-pent-2-en-2-yl>benzoate 
• 136527-57-6 methyl 4-<5-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-pent-1-en-2-yl>benzoate 
• 139577-58-5 4-<5-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-pent-2-en-2-yl>benzoic acid 
• 136527-58-7 4-<5-(2,4-diamino-6(1H)-pyrimidinon-5-yl)-pent-1-en-2-yl>benzoic acid 

Relevant academic research and scientific papers

Synthesis of 10-substituted "open-chain" analogues of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF, lometrexol)

Several novel and very potent folate antimetabolites, structurally based upon our previously described "open-chain" version of DDATHF but carrying 1-carbon substituents in the 10-position, have been synthesized. A key synthetic sequence involving a pallad

L-glutamic acid derivatives

Substituted pyrimidin-5-yl derivatives of L-glutamic acid are anti-neoplastic agents. A typical embodiment is N-{4-[6-(2,6-diamino-4-hydroxypyrimidin-5-yl)hex-1-en-3-yl]benzoyl}-L-glutamic acid.