139577-61-0Relevant articles and documents
Synthesis of 10-substituted "open-chain" analogues of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF, lometrexol)
Taylor, Edward C.,Schrader, Thomas H.,Walensky, Loren D.
, p. 19 - 32 (2007/12/18)
Several novel and very potent folate antimetabolites, structurally based upon our previously described "open-chain" version of DDATHF but carrying 1-carbon substituents in the 10-position, have been synthesized. A key synthetic sequence involving a pallad