139579-42-3

Upstream product

• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 
• 67-64-1 acetone 
• 870-63-3 prenyl bromide 

Downstream Products

• 206664-30-4 2-methyl-4-[2-(1-hydroxyprop-2-yn-1-yl)-4-methoxyphenoxy]but-2-ene 

Relevant academic research and scientific papers

A nickel(ii)-catalyzed asymmetric intramolecular Alder-ene reaction of 1,7-dienes

A highly diastereo- and enantioselective intramolecular Alder-ene reaction with an alkene as the enophile has been developed by using a chiral N,N′-dioxide/nickel(ii) complex as the catalyst. This protocol provides a facile route towards the synthesis of diverse 3,4-disubstituted chroman, tetrahydroquinoline, piperidine and thiochroman derivatives in high yields with good to excellent diastereo- and enantioselectivities.

ABCA1 ELEVATING COMPOUNDS

The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCAl production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrom

ABCA1 elevating compounds

The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrom

Enantioselective alkynylation reactions to aldehydes: The effects of aromatic substituents upon the enantioselectivity

Asymmetric alkynylation reactions to linear alkyl and substituted aromatic aldehydes have been accomplished in good yields and with a range of selectivities. For aromatic aldehydes we observed that the selectivity of the alkynylation reaction appears to d

A diastereoselective cobalt-mediated synthesis of benzopyrans using a novel variation of an intramolecular Nicholas reaction in the key cyclisation step: Optimisation and biological evaluation

A range of novel intramolecular cyclisation reactions between an organocobalt stabilised cation and a trisubstituted alkene have been accomplished that provide a concise route for the diastereoselective synthesis of a range of functionalised benzopyrans. In addition to the usual Lewis acids employed in the Nicholas reaction our studies have identified several other reagents for effecting the cyclisation reaction. In some examples sub-stoichiometric quantities of Lewis acid were successfully employed. These studies were concluded with a biological evaluation of specific derivatives, conducted by comparing their activity with the antihypertensive agent cromakalim 2, a drug whose mode of action is known to occur via the modulation of potassium channel activity.

Biosynthetic Studies on Tajixanthone and Shamixanthone, Polyketide Hemiterpenoid Metabolites of Aspergillus variecolor

The biosynthesis of tajixanthone and related metabolites of Aspergillus variecolor has been studied by incorporation experiments with simple and advanced precursors labelled with the stable isotopes 13C, 2H and 18O.Tajixanthone is shown to be derived through ring cleavage of an octaketide-derived anthraquinone with introduction of two dimethylallyl moieties.From the results of isotopic labelling experiments and chemical studies on model compounds, an overall biosynthetic pathway is proposed and information on the mechanisms of interconversion of proposed intermediates is obtained.