13958-91-3

Basic information

• Product Name: 3,5-Dibromopyridine-4-carboxylic acid
• Synonyms: 3,5-Dibromo-4-pyridinecarboxylic acid;3,5-Dibromoisonicotinic acid;3,5-DibroMopyridine-4-carboxylic acid;4-Pyridinecarboxylic acid, 3,5-dibroMo-;3,5-dibromoisonicotinic acid C6H3Br2NO2 280.90
• CAS NO: 13958-91-3
• Molecular Formula: C₆H₃Br₂NO₂
• Molecular Weight: 280.91
• Mol File: 13958-91-3.mol

Chemical Properties

• Melting Point: 62-64℃
• Boiling Point: 409.99 °C at 760 mmHg
• Flash Point: 201.755 °C
• Appearance: /
• Density: 2.202
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.652
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3,5-Dibromopyridine-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dibromopyridine-4-carboxylic acid(13958-91-3)
• EPA Substance Registry System: 3,5-Dibromopyridine-4-carboxylic acid(13958-91-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38-43
• Safety Statements: 26-36/37
• WGK Germany: 3
• Hazardous Substances Data: 13958-91-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
3,5-Dibromopyridine-4-carboxylic acid is used as an intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into the molecular structures of various drugs. Its unique structure allows for the development of new therapeutic agents with potential applications in treating different diseases.
Used in Agrochemical Production:
In the agrochemical industry, 3,5-Dibromopyridine-4-carboxylic acid is used as a key component in the production of pesticides and other crop protection agents. Its chemical properties make it suitable for creating compounds that can effectively control pests and diseases in agriculture.
Used in Organic Synthesis:
3,5-Dibromopyridine-4-carboxylic acid is utilized as a building block in organic synthesis, contributing to the creation of a wide range of organic compounds. Its reactivity and structural features are valuable for the development of new organic molecules with various applications in different industries.
Safety Precautions:
It is crucial to handle and store 3,5-Dibromopyridine-4-carboxylic acid with care due to its corrosive nature. Proper safety measures should be taken to prevent skin and eye irritation, ensuring that the compound does not come into direct contact with these sensitive areas.

InChI:InChI=1/C6H3Br2NO2/c7-3-1-9-2-4(8)5(3)6(10)11/h1-2H,(H,10,11)

Upstream product

• 625-92-3 3,5-dibromopyridine 
• 124-38-9 carbon dioxide 

Relevant articles and documents

Oximino-piperidino-piperidine-based CCR5 antagonists. Part 2: Synthesis, SAR and biological evaluation of symmetrical heteroaryl carboxamides

The synthesis, SAR and biological evaluation of symmetrical amide analogues of our clinical candidate SCH 351125 are described. A series of potent and orally bioavailable CCR5 antagonists containing symmetrical 2,6-dimethyl isonicotinamides and 2, 6-dimethyl pyrimidines amides were generated with enhanced affinity for the CCR5 receptor.

Synthesis of 4-alkyl-3,5-dibromo-, 3-bromo-4,5-dialkyl- and 3,4,5-trialkylpyridines via sequential metalation and metal-halogen exchange of 3,5-dibromopyridine

Lithiation of 3,5-dibromopyridine with LDA and subsequent reaction with electrophiles provided 4-alkyl-3,5-dibromopyridines 2 in high yield. 3-Bromo-4,5-dialkylpyridines 3 were synthesized by metal-halogen exchange of 2 with one equivalent n-BuLi and reaction with a second electrophile. Further metal-halogen exchange of 3 and reaction with a third electrophile provided 3,4,5-trisubstituted pyridines 4.