1395895-06-3Relevant academic research and scientific papers
Synthesis and biological evaluation of a fluorescent analog of phenytoin as a potential inhibitor of neuropathic pain and imaging agent
Walls, Thomas H.,Grindrod, Scott C.,Beraud, Dawn,Zhang, Li,Baheti, Aparna R.,Dakshanamurthy, Sivanesan,Patel, Manoj K.,Brown, Milton L.,MacArthur, Linda H.
supporting information, p. 5269 - 5276 (2012/11/07)
Here we report on a novel fluorescent analog of phenytoin as a potential inhibitor of neuropathic pain with potential use as an imaging agent. Compound 2 incorporated a heptyl side chain and dansyl moiety onto the parent compound phenytoin and produced greater displacement of BTX from sodium channels and greater functional blockade with greatly reduced toxicity. Compound 2 reduced mechano-allodynia in a rat model of neuropathic pain and was visualized ex vivo in sensory neuron axons with two-photon microscopy. These results suggest a promising strategy for developing novel sodium channel inhibitors with imaging capabilities.
