1396010-91-5Relevant academic research and scientific papers
Chiral-Sc catalyzed asymmetric Michael addition/protonation of thiols with enones in water
Kitanosono, Taku,Sakai, Masaru,Ueno, Masaharu,Kobayashi, Shu
experimental part, p. 7134 - 7147 (2012/10/08)
Asymmetric Michael reactions and enantioselective protonations between enones and thiols were catalyzed by a Sc(OTf)3-chiral 2,2′-bipyridine complex in water. The remarkable governing of the enantioselectivity for simple introduction of protons despite their abnormally high mobility in water may provide us with new synthetic opportunities as well as significant chemical advances.
