139607-30-0Relevant articles and documents
PBN (phenyl-N-tert-butylnitrone)-derivatives are effective in slowing the visual cycle and rhodopsin regeneration and in protecting the retina from light-induced damage
Stiles, Megan,Moiseyev, Gennadiy P.,Budda, Madeline L.,Linens, Annette,Brush, Richard S.,Qi, Hui,White, Gary L.,Wolf, Roman F.,Ma, Jian-Xing,Floyd, Robert,Anderson, Robert E.,Mandal, Nawajes A.
, (2016/02/18)
A2E and related toxic molecules are part of lipofuscin found in the retinal pigment epithelial (RPE) cells in eyes affected by Stargardt's disease, age-related macular degeneration (AMD), and other retinal degenerations. A novel therapeutic approach for t
Stereoselective synthesis of fluoroalkenoates and fluorinated isoxazolidinones: N-substituents governing the dual reactivity of nitrones
Prakash, G.K. Surya,Zhang, Zhe,Wang, Fang,Rahm, Martin,Ni, Chuanfa,Iuliucci, Marc,Haiges, Ralf,Olah, George A.
supporting information, p. 831 - 838 (2014/01/23)
α-Fluoroalkenoates and 4-fluoro-5-isoxazolidinones are of vast interest due to their potential biological applications. We now demonstrate the syntheses of (E)-α-fluoroalkenoates and 4-fluoro-5-isoxazolidinones by the reactions between nitrones and α-fluoro-α-bromoacetate. By altering N-substituents in nitrones, (E)-α-fluoroalkenoates and 4-fluoro-5-isoxazolidinones can be achieved, respectively, with high chemo- and stereoselectivities. Experimental and computational studies have been conducted to elucidate the reaction mechanisms. Linear free energy relationship studies further revealed that the N-substituent effects are primarily of electronic origin. Copyright
Nitrone derivatives
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, (2008/06/13)
A compound represented by the figure (1) or a pharmaceutically acceptable salt thereof is useful as medicament for treating retinal degenerative disorders: wherein Ar is optionally substitued phenyl or optionally substituted heteroaryl;. n is 0, 1 or 2; W
