13961-36-9Relevant articles and documents
Montmorillonite clay-catalysed synthesis of cyclic allylamines
Hachemaoui, A?cha,Belbachir, Mohammed
, p. 124 - 125 (2005)
A mild and efficient catalytic method for the synthesis of cyclic N-allylamines using an acid-exchanged montmorillonite as a catalyst is described.
Unique spirocyclopiperazinium salt I: Synthesis and structure-activity relationship of spirocyclopiperazinium salts as analgesics
Gao, Feng-Li,Wang, Xin,Zhang, Hong-Mei,Cheng, Tie-Ming,Li, Run-Tao
, p. 1535 - 1537 (2007/10/03)
Based on the structure of compound 3, two series of spirocyclopiperazinium derivatives 7a-n and 10a-h were synthesized and evaluated for their in vivo analgesic and sedative activities. Compounds 7f and 10c were discovered to exhibit excellent analgesic activity. Structure-activity relationships revealed that anion of the quaternary salt affected the analgesic and sedative activity significantly; the allyl group is a most effective group among the compounds 7a-n; the electron-released substitute on the aromatic ring is favorable to increase the analgesic activity.
3-(4-Substituted piperazino)-1-xanthene-9-carbonyloxy-propanes
-
, (2008/06/13)
The invention relates to novel piperazine derivatives having the formula (I), STR1 wherein R1 represents a C1-5 alkyl group having optionally a phenyl, trimethoxyphenyl, phenoxy, methoxy-cyclohexyl or heptamethyleneimino substituent