139613-48-2

Basic information

• Product Name: Hydrazinecarboximidamide, 2-[(2-chloro-4-hydroxy-5-methoxyphenyl)methylene]-N-hydroxy-, mono(4-methylbenzenesulfonate) (salt)
• CAS NO: 139613-48-2
• Molecular Formula: C9H11ClN4O3.C7H8O3S
• Molecular Weight: 430.869
• Mol File: 139613-48-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Hydrazinecarboximidamide, 2-[(2-chloro-4-hydroxy-5-methoxyphenyl)methylene]-N-hydroxy-, mono(4-methylbenzenesulfonate) (salt)(CAS DataBase Reference)
• NIST Chemistry Reference: Hydrazinecarboximidamide, 2-[(2-chloro-4-hydroxy-5-methoxyphenyl)methylene]-N-hydroxy-, mono(4-methylbenzenesulfonate) (salt)(139613-48-2)
• EPA Substance Registry System: Hydrazinecarboximidamide, 2-[(2-chloro-4-hydroxy-5-methoxyphenyl)methylene]-N-hydroxy-, mono(4-methylbenzenesulfonate) (salt)(139613-48-2)

Safety Data

• Hazardous Substances Data: 139613-48-2(Hazardous Substances Data)

Upstream product

• 18268-76-3 6-chlorovaniline 
• 36826-58-1 N-hydroxy-N'-aminoguanidine p-toluenesulphonate 

Relevant articles and documents

Synthesis and anti-HIV-1 activity of N-hydroxy-N1-aminoguanidines

The synthesis of 13 new Schiff bases of N-hydroxy-N1-aminoguanidines (1-13) starting from thiosemicarbazide are reported. These new derivatives were for the first time tested against infection by the Human Immunodeficiency Virus Type 1 (HIV-1) using the human T-lymphocyte cell line. Four N-hydroxy-N1-aminoguanidines (3, 4, 8 and 11) exhibited HIV-I inhibition in the micromolar range. The most active compound, [1-(1'-chloro-2'-hydroxy-3'-methoxybenzylidene)amino]-3-hydroxyguanidi ne(11) inhibited HIV-1 by 96% at 10 μg/ml concentration. All the derivatives exhibited substantial cytotoxicity at 320 μg/ml concentration. The results indicate that the activity against HIV-1 increases with increasing hydrophobicity and substituents with electron-donating properties.