18268-76-3

Basic information

• Product Name: 2-CHLORO-4-HYDROXY-5-METHOXY-BENZALDEHYDE
• Synonyms: AKOS B029087;2-CHLORO-4-HYDROXY-5-METHOXY-BENZALDEHYDE;ASINEX-REAG BAS 08767097;CHEMBRDG-BB 4004195;TIMTEC-BB SBB010751;AKOS BB919;ART-CHEM-BB B029087;2-chloro-4-hydroxy-5-methoxybenzaldehyde(SALTDATA: FREE)
• CAS NO: 18268-76-3
• Molecular Formula: C₈H₇ClO₃
• Molecular Weight: 186.59
• Mol File: 18268-76-3.mol

Chemical Properties

• Melting Point: 167-168 °C
• Boiling Point: 307.2°C at 760 mmHg
• Flash Point: 139.6°C
• Appearance: /
• Density: 1.377g/cm³
• Vapor Pressure: 0.000406mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: -20°C, Inert atmosphere
• PKA: 6.83±0.23(Predicted)
• CAS DataBase Reference: 2-CHLORO-4-HYDROXY-5-METHOXY-BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-HYDROXY-5-METHOXY-BENZALDEHYDE(18268-76-3)
• EPA Substance Registry System: 2-CHLORO-4-HYDROXY-5-METHOXY-BENZALDEHYDE(18268-76-3)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 18268-76-3(Hazardous Substances Data)

Usage

Uses

2-Chloro-4-hydroxy-5-methoxybenzaldehyde is a metabolite of chlorinated lignin hydrolyzate.

InChI:InChI=1/C8H7ClO3/c1-12-8-2-5(4-10)6(9)3-7(8)11/h2-4,11H,1H3

Upstream product

• 302321-78-4 4-(5,5-dimethyl-[1,3]dioxan-2-yl)-6,6-dimethoxy-cyclohexa-2,4-dienone 
• 182345-46-6 5,5-Dimethyl-2-(4-hydroxy-3-methoxyphenyl)-1,3-dioxane 
• 18093-05-5 6-chloroverataldehyde 
• 37686-56-9 6-chloro-3,4-dihydroxybenzaldehyde 
• 74-88-4 methyl iodide 
• 84333-02-8 6-chlorovanillin acetate 
• 160925-76-8 1,3-bis(4'-acetoxy-6'-chloro-3'-methoxyphenyl)-3-hydroxy-1-propanone 

Downstream Products

• 67289-06-9 2-chloro-5-methoxy-hydroquinone 
• 18268-69-4 5,6-Dichlorovanillin 
• 24605-23-0 2-chloro-5-methoxybenzoquinone 
• 75024-38-3 3-bromo-2-chloro-4-hydroxy-5-methoxy-benzaldehyde 
• 99854-25-8 5-chloro-2-methoxy-p-hydroquinone diacetate 
• 139613-48-2 C₉H₁₁ClN₄O₃*C₇H₈O₃S 
• 37686-56-9 6-chloro-3,4-dihydroxybenzaldehyde 
• 69240-98-8 6-chloroacetoguaiacone 
• 160925-76-8 1,3-bis(4'-acetoxy-6'-chloro-3'-methoxyphenyl)-3-hydroxy-1-propanone 
• 1036383-44-4 2-chloro-4-(4-chloro-2-fluoro-benzyloxy)-5-methoxy-benzaldehyde 
• 1264752-18-2 (5Z)-5-[(4-{[2,4-bis(trifluoromethyl)benzyl]oxy}-2-chloro-5-methoxyphenyl)methylidene]-4-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}-1,3-thiazol-2(5H)-one 
• 1264752-19-3 (5Z)-5-[(4-{[2,4-bis(trifluoromethyl)benzyl]oxy}-2-chloro-5-methoxyphenyl)methylidene]-4-(methylamino)-1,3-thiazol-2(5H)-one 
• 1264753-87-8 4-{[2,4-bis(trifluoromethyl)benzyl]oxy}-2-chloro-5-methoxybenzaldehyde 
• 1036383-41-1 4-(1H-benzoimidazol-2-ylmethoxy)-2-chloro-5-methoxy-benzaldehyde 

Relevant articles and documents

Unanticipated participation of HCl in nucleophilic chlorination reaction: Expedient route to meta chlorophenols

o-Quinone monoketals participated in a 1,4-addition reaction with HCl furnishing m-chlorophenols in high yields. Several readily available o-quinone monoketals were selected to display the generality of this serendipitous and unprecedented reaction and the results are presented herein.

COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

PYRAZOLO-HETEROARYL COMPOUNDS USEFUL TO TREAT TNF-ALPHA AND IL-1 MEDIATED DISEASES

A compound of formula (I) wherein the groups R1-R4, X and Y are as defined in the specification, useful to treat TNF-Alpha and IL-1 mediated diseases.

Preparation and properties of chlorinated syringic acids, acetosyringones, acetoguaiacones and methoxy-p-hydroquinones components of pulp bleaching effluents

A range of chlorinated phenols which serve as standards for compounds occurring in effluents from the bleaching of wood pulps with chlorine-containing reagents has been prepared. The chlorinated phenols include chlorosyringic acids, chloroacetosyringones, chloroacetoguaiacones, 5-chloro-2-methoxy-p-hydroquinone and chloro-2,6-dimethoxy-p-hydroquinones. With the exception of the ring-chlorinated acetoguaiacones which were prepared by reaction of chlorovanillin acetates with diazomethane, the compounds were obtained by direct chlorination of appropriate phenols or their acetates. Gas chromatographic and mass spectrometric data for the acetylated phenols are given.