139619-83-3

Upstream product

• 37610-80-3 1,3-dioxolan-2-ylethylmagnesium bromide 
• 194208-59-8 2-{2-[(3R,3aR,5R,7aR)-7-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methyl-cyclohex-1-enylethynyl]-3-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-3a-methyl-2,3,3a,4,5,7a-hexahydro-1H-inden-5-yl]-ethyl}-[1,3]dioxolane 
• 139619-84-4 Trifluoro-methanesulfonic acid (1R,3aR,6R,7aR)-6-(2-[1,3]dioxolan-2-yl-ethyl)-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl ester 
• 139619-75-3 [(1R,3aR,6R,7aR)-6-(2-[1,3]Dioxolan-2-yl-ethyl)-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yloxy]-trimethyl-silane 
• 139619-81-1 [(1R,3aR,7aR)-1-((R)-5-Methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yloxy]-trimethyl-silane 
• 194414-15-8 2-[(R)-2-((1R,3aR,4S,7aR)-4-Hydroxy-7a-methyl-octahydro-inden-1-yl)-propyl]-4-methoxymethoxy-4-methyl-pentanenitrile 
• 139619-80-0 (1R,6R,7R)-7-[(R)-6-(methoxymethoxy)-6-methylheptan-2-yl]-6-methylbicyclo[4.3.0]nonan-2-one 
• 139619-76-4 (1R,3aR,7aR)-1-((R)-5-Methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-1,2,3,3a,7,7a-hexahydro-inden-4-one 
• 139619-79-7 (1R,2S,6R,7R)-7-[(R)-6-(methoxymethoxy)-6-methylheptan-2-yl]-6-methylbicyclo[4.3.0]nonan-2-ol 
• 139619-77-5 4-Methoxymethoxy-4-methyl-pentanenitrile 
• 116506-67-3 TB 
• 6789-52-2 4-hydroxy-4-methylpentanenitrile 
• 35979-69-2 4-bromo-2-methyl-2-butanol 
• 18742-02-4 2-bromo-2-(2-ethyl)dioxolane 

Downstream Products

• 139619-73-1 (1R,3S)-5-[2-[(1R,3aS,6S,7aR)-6-(3,3-Dimethoxy-propyl)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexane-1,3-diol 

Relevant academic research and scientific papers

Copper-mediated alkylation of vitamin DC-ring. Synthesis of C11-functionalized 1α,25-dihydroxyvitamin D3

This work describes our studies on the functionalization at C11 of CD-ring fragments of vitamin D3 using organocopper reagents. As an application, an efficient, convergent synthesis of 11α-[3,3-(dimethoxy)propyl] calcitriol analogue 2, which ma

AN EFFICIENT ROUTE TO 1α,25-DIHYDROXYVITAMIN D3 FUNCTIONALIZED AT C-11

An efficient route to vitamin D3 analogues functionalized at C-11 is described.Key features of this synthesis are: (i) the development of a novel and efficient route for the introduction of the 25-hydroxylated side chain, present in the most im