139622-54-1

Basic information

• Product Name: 2H-Pyran, tetrahydro-2-(2-phenoxyethoxy)-
• CAS NO: 139622-54-1
• Molecular Formula: C13H18O3
• Molecular Weight: 222.284
• Mol File: 139622-54-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2H-Pyran, tetrahydro-2-(2-phenoxyethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran, tetrahydro-2-(2-phenoxyethoxy)-(139622-54-1)
• EPA Substance Registry System: 2H-Pyran, tetrahydro-2-(2-phenoxyethoxy)-(139622-54-1)

Safety Data

• Hazardous Substances Data: 139622-54-1(Hazardous Substances Data)

Upstream product

• 17739-45-6 2-(2-bromoethoxy)tetrahydropyran 
• 108-95-2 phenol 
• 110-87-2 3,4-dihydro-2H-pyran 
• 122-99-6 2-Phenoxyethanol 

Downstream Products

• 122-99-6 2-Phenoxyethanol 
• 6192-44-5 2-phenoxyethyl acetate 

Relevant articles and documents

Solvent-Free Tetrahydropyranylation of Alcohols with Sulfamic Acid as Reusable Catalyst

An efficient H2NSO3H-catalyzed solvent-free tetrahydropyranylation of various alcohols at room temperature was investigated. The features of mild conditions, cost-efficient catalyst, simple work-up, and the recyclability of the catalyst were displayed in this article.

AI(OTf)3 - A highly efficient catalyst for the tetrahydropyranylation of alcohols under solvent-free conditions

A simple and highly efficient method has been developed for the tetrahydropyranylation of alcohols by their reaction with 3,4-dihydro-2H-pyran (DHP) using a catalytic amount (0.01-1 mol%) of aluminium triflate under solvent-free conditions. The effect of various factors like temperature, amount of the catalyst, and molar ratio of substrates on the reaction conditions has also been studied. The comparative study of tetrahydropyranylation of benzyl alcohol using various catalysts including some reported ones shows the efficiency of this catalyst.

Efficient method for tetrahydropyranylation/depyranylation of phenols and alcohols using a solid acid catalyst with Wells-Dawson structure

A simple and efficient procedure to form 2-tetrahydropyranyl acetals of phenols and alcohols is reported. Wells-Dawson heteropolyacid catalyst is used both in bulk form or supported on silica, reaction conditions include room temperature and toluene as solvent. Fast deprotection of THP-acetals can be attained by mere change of the solvent using THF-1% MeOH. In both reactions the supported catalyst is easily recoverable and reusable, and the yields are good to excellent.