139631-20-2

Upstream product

• 186581-53-3 diazomethane 
• 139631-19-9 (6E,8E,10E)-(3S,4S)-3-(tert-Butyl-diphenyl-silanyloxy)-4,6,10-trimethyl-11-(2-methyl-oxazol-4-yl)-5-oxo-undeca-6,8,10-trienoic acid 
• 10200-43-8 2-methyl-4-carbethoxy-1,3-oxazole 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 139631-17-7 (2S,4S,5S,7E,9E,11E)-4-((tert-Butyldiphenylsilyl)oxy)-1,2-(isopropylidenedioxy)-5,7,11-trimethyl-12-(2'-methyloxazol-4'-yl)-7,9,11-dodecatrien-6-one 
• 139631-13-3 Ethyl (2S,3S,5S)-3-hydroxy-5,6-(isopropylidenedioxy)-2-methylhexanoate 
• 139630-92-5 (1'E,3'E)-4-(4'-(Methoxycarbonyl)-2'-methyl-1',3'-butadienyl)-2-methyloxazole 
• 139630-91-4 (E)-2-methyl-3-(2-methyloxazol-4-yl)acrylaldehyde 
• 139655-28-0 Methyl (1R(1'E,3'E,5'E),2S,3S,5S)-3-O-(tert-butyldiphenylsilyl)-1-(1',5'-dimethyl-6'-(2-methyloxazol-4-yl)-1',3',5'-hexatrienyl)-2-methyl-2,4-dideoxymannopyranoside 
• 139631-15-5 (2RS,4S,5S,7S)-5-((tert-Butyldiphenylsilyl)oxy)-2-(diethylphosphono)-7,8-(isopropylidenedioxy)-4-methyloctan-3-one 
• 139655-29-1 (3S,4S,6E,8E,10E)-3-((tert-Butyldiphenylsilyl)oxy)-4,6,10-trimethyl-11-(2'-methyloxazol-4'-yl)-1-oxo-6,8,10-undecatrien-5-one 
• 139631-14-4 Ethyl (2S,3S,5S)-3-((tert-butyldiphenylsilyl)oxy)-5,6-(isopropylidenedioxy)-2-methylhexanoate 
• 139631-10-0 (2'R,3'S,5'S,4R,5S)-3-(3'-Hydroxy-5',6'-(isopropylidenedioxy)-2'-(methylthio)hexanoyl)-4-methyl-5-phenyl-2-oxazolidinone 
• 139631-11-1 (3'S,5'S,4R,5S)-3-(3'-Hydroxy-5',6'-(isopropylidenedioxy)hexanoyl)-4-methyl-5-phenyl-2-oxazolidinone 

Relevant academic research and scientific papers

Synthesis of the Lower Subunit of Rhizoxin

Full details of a study leading to a synthesis of the optically active C13-C26 lower subunit of rhizoxin including the side-chain chromophore characteristic of the full class of antimitotic agents are described.A key element of the synthesis is the stereoselective introduction of the C18-C19 trisubstituted olefin through use of a Wadsworth-Horner-Emmerson condensation of 3 with β-keto phosphonate 38 bearing resident functionality suitable for the diastereoselective introduction of C15-C17 employing a hydroxyl-directed reduction of the resultant β-hydroxy ketone.