139633-19-5

Upstream product

• 5099-99-0 N-benzyl-3-hydroxy-3-phenylpropanamide 
• 57152-94-0 (E)-N-benzylcinnamamide 

Downstream Products

• 139633-20-8 cis-N-benzylthiocinnamamide 

Relevant academic research and scientific papers

Reactivity and diastereoselectivity of Michael additions of amines to achiral α,β-unsaturated thioamides

Heterocyclic, aliphatic amines add to acyclic and cyclic α,β-unsaturated thioamides yielding β-amino-functionalized derivatives. In the case of cyclic acceptors, the formation of both kinetic and thermodynamically controlled products is observed. Tailorin

Thionation of ω-hydroxy amides with Lawesson's reagent: Synthesis of thioenamides and sulfur-containing heterocycles

The thionation of ω-hydroxy amides with Lawesson's reagent [LR: 2,4- bis(p-methoxyphenyl)-1,3,2,4-dithiaphosphetane-2,4-disulfide] is described. The treatment of 3-hydroxy amides 1 with LR exclusively gave thioenamides 2 in fair yields. The treatment of 4-hydroxy amides 5 with LR yielded sulfur- containing heterocycles such as tetrahydrothiophene-2-imines 6 and tetrahydrothiophene-2-thione 7a through cyclization of intermediates, 4- mercapto amides 8. The 5-hydroxy amides 13 also reacted with LR to afford tetrahydrothiopyrane-2-thione 14 as the the sole product.

Sulfur-containing heterocycles derived by the reaction of hydroxy-amides and Lawesson's reagent

A simple one-pot reaction between hydroxy-amides (1), located 1,3- or 1,4- to each other, and Lawesson's reagent (LR) gives sulfur-containing heterocycles such as tetrahydrothiophene-2-imines (4), tetrahydrothiophene-2-thione (5) and tetrahydrothiopyran-2

Photochemical Isomerization of N-Monosubstituted α,β-Unsaturated Thioamides to Iminothietanes

Photochemical isomerization of thiomethacryl-, thiotiglyl-, and thiocrotonoamides gives iminothietanes, N-(2-thietanylidene)amines, in good yields.The iminothietanes reverted quantitatively to the starting materials on heating.Use of Michler's ketone or t