139645-87-7Relevant academic research and scientific papers
Synthesis and antiviral activities of novel acylhydrazone derivatives targeting HIV-1 capsid protein
Tian, Baohe,He, Meizi,Tang, Shixing,Hewlett, Indira,Tan, Zhiwu,Li, Jiebo,Jin, Yinxue,Yang, Ming
experimental part, p. 2162 - 2167 (2009/12/25)
HIV-1 capsid protein (CA) plays important roles in the viral replication cycle. A number of acylhydrazone derivatives that act as inhibitors of HIV-1 CA assembly, were designed and synthesized. The synthesized compounds were tested for their antiviral activities and cytotoxicities using CEM cells. Some derivatives also were assayed for their ability to inhibit HIV-1 CA assembly in vitro. Among them, compounds 14f and 14i display the most promising potency with EC50 values of 0.21 and 0.17 μΜ, respectively.
Inhibitors of bacterial cystathionine β-lyase: Leads for new antimicrobial agents and probes of enzyme structure and function
Ejim, Linda J.,Blanchard, Jan E.,Koteva, Kalinka P.,Sumerfield, Rachael,Elowe, Nadine H.,Chechetto, Jonathan D.,Brown, Eric D.,Junop, Murray S.,Wright, Gerard D.
, p. 755 - 764 (2007/10/03)
The biosynthesis of methionine is an attractive antibiotic target given its importance in protein and DNA metabolism and its absence in mammals. We have performed a high-throughput screen of the methionine biosynthesis enzyme cystathionine β-lyase (CBL) a
