1396516-53-2

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 1397275-17-0 potassium tert-butyl butyl{(trifluoroborato)methyl}carbamate 
• 1396514-51-4 tert-butyl n-butyl{(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl}carbamate 
• 59255-58-2 tert-butyl butylcarbamate 
• 164648-84-4 4-cyanophenyl dimethylsulfamate 

Relevant academic research and scientific papers

Pd-catalyzed Suzuki-Miyaura cross-coupling reactions between sulfamates and potassium Boc-protected aminomethyltrifluoroborates

Sulfamates were studied as the electrophilic partners in the palladium-catalyzed Suzuki-Miyaura cross-coupling reaction with potassium Boc-protected primary and secondary aminomethyltrifluoroborates. A broad range of substrates was successfully coupled to provide the desired products. Complex molecules containing a new carbon-carbon bond and an aminomethyl moiety could be prepared through this developed method.

Potassium Boc-protected secondary aminomethyltrifluoroborates: Synthesis and Suzuki-Miyaura cross-coupling reactions

Seven potassium Boc-protected secondary aminomethyltrifluoroborates were prepared in a standardized two-step process. The Suzuki-Miyaura cross-coupling reaction was studied with this new class of nucleophiles, and a large variety of aryl and hetaryl chlorides provided the desired products in good to excellent yields, thereby allowing easy access to secondary aminomethyl substructures.