139670-04-5 Usage
Uses
Used in Pharmaceutical Industry:
2-Bromo-4-chlorothiazole-5-carboxylic acid is used as an intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into various drug molecules, enhancing their therapeutic properties and targeting specific biological pathways.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Bromo-4-chlorothiazole-5-carboxylic acid serves as a key intermediate in the production of agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used in Dye and Pigment Production:
2-Bromo-4-chlorothiazole-5-carboxylic acid is utilized in the manufacturing of dyes and pigments due to its chemical structure that can impart specific color characteristics and properties to these substances.
Used in Organic Chemistry Research:
As a versatile compound, 2-Bromo-4-chlorothiazole-5-carboxylic acid is used in organic chemistry research for the synthesis of various derivatives and analogues, expanding the scope of chemical compounds available for different applications.
Check Digit Verification of cas no
The CAS Registry Mumber 139670-04-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,6,7 and 0 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 139670-04:
(8*1)+(7*3)+(6*9)+(5*6)+(4*7)+(3*0)+(2*0)+(1*4)=145
145 % 10 = 5
So 139670-04-5 is a valid CAS Registry Number.
139670-04-5Relevant articles and documents
Azoles. Part 8. Metallation and Bromine -> Lithium Exchange Reactions of Polyhalogenothiazoles
Athmani, Salah,Bruce, Andrew,Iddon, Brian
, p. 215 - 219 (2007/10/02)
2,4-Dichloro- and 2,4-dibromo-thiazole were deprotonated at position-5 with LiN(iPr)2 in THF at -78 deg C and the resulting lithium compound was quenched with various reagents, to yield various trisubstituted thiazoles. 2,5-Dibromo-4-chlorothiazole reacted with n-butyllithium in THF at -78 deg C at position-5 and the resulting lithium derivative gave 2-bromo-4-chloro-5-substituted thiazoles when quenched with the appropriate reagent.Both the 2- and 5-bromine-atoms were reactive in diethyl ether. 2,5-Dibromothiazole failed to deprotonate at position-4 under various reaction conditions, whereas treatment of 2,4,5-tribromothiazole with 1 mole equivalent of n-butyllithium in THF at -90 deg C, followed by addition of dimethyl disulfide after 30 min, gave a high yield of the 2,5-bis(methylthio)-compound.The tribromo-compound was also treated with 1 mole equivalent of n-butyllithium or methyllithium under various reaction conditions and the products formed after hydrolysis were analysed by 1H NMR spectroscopy.The 5-bromine-atom is the most reactive and greater selectivity is obtained with methyllithium.
