139705-41-2

Upstream product

• 36884-29-4 4-bromo-pent-4-enal 
• 151654-85-2 (E)-6-Bromo-hepta-2,6-dienoic acid methyl ester 
• 151654-86-3 6-Bromo-3-vinyl-hept-6-enal 
• 92975-38-7 4-bromo-4-pentenoic acid tert-butyl ester 
• 137609-79-1 (2E)-6-Bromo-2,6-heptadien-1-ol 
• 64180-78-5 4-bromopent-4-en-1-ol 
• 139705-39-8 Benzyl-(6-bromo-3-vinyl-hept-6-enyl)-amine 

Relevant academic research and scientific papers

Synthesis of Bicyclic Nitrogen Compounds via Tandem Intramolecular Heck Cyclization and Subsequent Trapping of Intermediate ?-Allylpalladium Complexes

Intramolecular palladium-mediated three-component cyclization of substrates containing vinyl halide, olefin, and sulfonamide moieties to generate a diverse group of nitrogen heterocycles have been developed.The methodology has been applied to construction of both fused and bridged bicyclic systems.The strategy can also be used for spirocyclizations.This chemistry involves regiospecific generation of ?-allylpalladium complexes via Heck reactions of vinyl halides and simple olefins, followed by nucleophilic addition of sulfonamide anions to these intermediates.

A Palladium-Mediated Approach to Construction of Nitrogen Heterocycles

Sequential regiospecific C-C and C-N bondforming reactions via a novel variation of the Heck reaction can be used to synthesize nitrogen-containing heterocyclic systems.